Synthesis of pipecolic acid derivatives via Aza-Diels-Alder reactions of thio-substituted 1,3-butadienes with iminium salts

被引：9

作者：

Chou, SSP ^{[1
]}

Hung, CC ^{[1
]}

机构：

[1] Fu Jen Catholic Univ, Dept Chem, Taipei 242, Taiwan

来源：

SYNTHETIC COMMUNICATIONS | 2002年 / 32卷 / 20期

关键词：

D O I：

10.1081/SCC-120013722

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The titled compounds 1a-b were readily prepared by thermal desulfonylation of thio-substituted-3-sulfolenes 2a-b. The Aza-Diels-Alder reactions of 1a-b with iminium salts derived from alkyl or aryl amine hydrochlorides and ethyl glyoxalate gave the pipecolic acid derivatives 3-4 in good yields with complete control of regiochemistry.

引用

页码：3119 / 3126

页数：8

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