Synthesis of Pyridazine Derivatives via Aza-Diels-Alder Reactions of 1,2,3-Triazine Derivatives and 1-Propynylamines

被引：13

作者：

Kodama, Takayuki ^{[1
]}

Sasaki, Ikuo ^{[1
]}

Sugimura, Hideyuki ^{[1
]}

机构：

[1] Aoyama Gakuin Univ, Fac Sci & Technol, Dept Chem & Biosci, Sagamihara, Kanagawa 2525258, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 13期

关键词：

CYCLOADDITION; INHIBITORS; AZAMERONE; ROUTE; ACID;

D O I：

10.1021/acs.joc.1c00851

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly regioselective method was developed for the preparation of pyridazine derivatives via the aza-Diels-Alder reaction of 1,2,3-triazines with 1-propynylamines under neutral conditions. This methodology allowed direct access to a wide range of 6-aryl-pyridazin-3-amines in high yields with good functional group compatibility. Key features of this strategy included a broad substrate scope and simple, metal-free, and neutral reaction conditions.

引用

页码：8926 / 8932

页数：7

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