The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin

被引：9
|
作者：
Ilic-Stojanovic, Snezana S. [1 ]
Nikolic, Vesna D. [1 ]
Nikolic, Ljubisa B. [1 ]
Zdravkovic, Aleksandar S. [2 ]
Kapor, Agnes J. [3 ]
Popsavin, Mirjana M. [4 ]
Petrovic, Slobodan D. [5 ]
机构：
[1] Univ Nis, Fac Technol, Leskovac 16000, Serbia
[2] Coll Text, Leskovac, Serbia
[3] Univ Novi Sad, Fac Sci, Dept Phys, Novi Sad 21000, Serbia
[4] Univ Novi Sad, Fac Sci, Dept Chem, Novi Sad 21000, Serbia
[5] Univ Belgrade, Fac Technol & Met, Belgrade 11000, Serbia
来源：
HEMIJSKA INDUSTRIJA | 2015年 / 69卷 / 04期
关键词：
naproxen; photodegradation; 2-hydroxypropyl-beta-cyclodextrin; inclusion complex; HYDROXYPROPYL-BETA-CYCLODEXTRIN; DISSOLUTION; POLY(VINYLPYRROLIDONE); PHOTODEGRADATION; AMLODIPINE; CHITOSAN; SYSTEMS;
D O I：
10.2298/HEMIND131128050I
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
The aim of this work was the preparation of the inclusion complex of naproxen with 2-hydroxypropyl-beta cyclodextrin (HP-beta-CD) in order to improve the physical and chemical properties of naproxen. The molecular inclusion complexes of naproxen with HP-beta-CD were prepared by using the co-precipitation method in the solid state with the molar ratio of 1:1. The structure of the obtained complex was characterized by using FTIR, H-1 NMR, UV-Vis and XRD methods. The testing of naproxen photostability by the UV-Vis method indicated the degradation to aromatic ketone, 2-acetyl-6-methoxynaphthalene. FTIR analysis showed that the degradation has started 15 days after the exposure of naproxen to daylight while the inclusion complex of naproxen:2-hydroxypropyl-beta-cyclodextrin was photostable for a period of 30 days.
引用
收藏
页码：361 / 370
页数：10
相关论文
共 50 条
  • [21] Preparation and characterization of spiro-acridine derivative and 2-hydroxypropyl-β-cyclodextrin inclusion complex
    Melo, Camila de Oliveira
    da Silva Rodrigues, Maria Salete
    Santos da Silva, Marcus Vinicius
    Marcelino, Henrique Rodrigues
    Rabello, Marcelo Montenegro
    de Moura, Ricardo Olimpio
    Oliveira, Elquio Eleamen
    JOURNAL OF MOLECULAR STRUCTURE, 2020, 1222 (1222)
  • [22] Comprehensive Physico-Chemical Characterization of a Serotonin Inclusion Complex with 2-Hydroxypropyl-β-Cyclodextrin
    Fateminasab, F.
    Bordbar, A. K.
    Shityakov, S.
    Saboury, A. A.
    JOURNAL OF SOLUTION CHEMISTRY, 2020, 49 (7-8) : 915 - 944
  • [23] Comprehensive Physico-Chemical Characterization of a Serotonin Inclusion Complex with 2-Hydroxypropyl-β-Cyclodextrin
    F. Fateminasab
    A. K. Bordbar
    S. Shityakov
    A. A. Saboury
    Journal of Solution Chemistry, 2020, 49 : 915 - 944
  • [24] Silylation of 2-hydroxypropyl-β-cyclodextrin
    M. K. Grachev
    A. V. Popkov
    I. I. Levina
    G. I. Kurochkina
    Russian Journal of General Chemistry, 2017, 87 : 1536 - 1541
  • [25] Ultrasound processed cuminaldehyde/2-hydroxypropyl-β-cyclodextrin inclusion complex: Preparation, characterization and antibacterial activity
    Cui, Haiying
    Siva, Subramanian
    Lin, Lin
    ULTRASONICS SONOCHEMISTRY, 2019, 56 : 84 - 93
  • [26] Silylation of 2-hydroxypropyl-β-cyclodextrin
    Grachev, M. K.
    Popkov, A. V.
    Levina, I. I.
    Kurochkina, G. I.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2017, 87 (07) : 1536 - 1541
  • [27] Evidence for the formation of a benzo[a]phenothiazine/2-hydroxypropyl-β-cyclodextrin inclusion complex using a fluorescence method
    Maafi, M
    Aaron, JJ
    Mahedero, MC
    Salinas, F
    APPLIED SPECTROSCOPY, 1998, 52 (01) : 91 - 95
  • [28] Evaluation Study of the Inclusion Complexes of Some Oxicams with 2-hydroxypropyl-β-cyclodextrin
    Suta, Lenuta-Maria
    Vlaia, Lavinia
    Fulias, Adriana
    Ledeti, Ionut
    Hadaruga, Daniel
    Mircioiu, Constantin
    REVISTA DE CHIMIE, 2013, 64 (11): : 1279 - 1283
  • [29] PREPARATION AND CHARACTERIZATION OF INCLUSION COMPLEXES BETWEEN REPAGLINIDE AND β-CYCLODEXTRIN, 2-HYDROXYPROPYL-β-CYCLODEXTRIN AND RANDOMLY METHYLATED β-CYCLODEXTRIN
    Nicolescu, Camelia
    Arama, Corina
    Monciu, Crina-Maria
    FARMACIA, 2010, 58 (01) : 78 - 88
  • [30] A study of the inclusion complex of bioactive thiadiazole derivative with 2-hydroxypropyl-β-cyclodextrin: Preparation, characterization and physicochemical properties
    Ol'khovich, Marina
    Sharapova, Angelica
    Blokhina, Svetlana
    Perlovich, German
    Skachilova, Sofia
    Shilova, Elena
    JOURNAL OF MOLECULAR LIQUIDS, 2019, 273 : 653 - 662
12345