PREPARATION AND CHARACTERIZATION OF INCLUSION COMPLEXES BETWEEN REPAGLINIDE AND β-CYCLODEXTRIN, 2-HYDROXYPROPYL-β-CYCLODEXTRIN AND RANDOMLY METHYLATED β-CYCLODEXTRIN

被引：0
|
作者：
Nicolescu, Camelia
Arama, Corina
Monciu, Crina-Maria
机构：
来源：
FARMACIA | 2010年 / 58卷 / 01期
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暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Repaglinide, an oral antidiabetic drug with short duration of action, administered in patients with type 2 diabetes mellitus exhibits very low water solubility and high lipophilicity. In order to evaluate the possibility of enhancing the drug's solubility, inclusion complexes between repaglinide and beta- cyclodextrin(beta CD), 2- hydroxypropyl-beta cyclodextrin (HP- beta-CD) and randomly methylated-beta cyclodextrin (RAMEB)) have been obtained by applying the following preparation methods: liophylisation, co-precipitation followed by filtration of the end-product and kneading method. The inclusion complexes were characterized by means of Nuclear Magnetic Resonance ((1)H-NMR, (13)C-NMR), Differential Scanning Calorimetry (DSC) and Infrared Spectroscopy (FT-IR). The results obtained confirmed the inclusion of repaglinide into the cyclodextrins cavity.
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页码：78 / 88
页数：11
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