PREPARATION AND CHARACTERIZATION OF INCLUSION COMPLEXES BETWEEN REPAGLINIDE AND β-CYCLODEXTRIN, 2-HYDROXYPROPYL-β-CYCLODEXTRIN AND RANDOMLY METHYLATED β-CYCLODEXTRIN

Repaglinide, an oral antidiabetic drug with short duration of action, administered in patients with type 2 diabetes mellitus exhibits very low water solubility and high lipophilicity. In order to evaluate the possibility of enhancing the drug's solubility, inclusion complexes between repaglinide and beta- cyclodextrin(beta CD), 2- hydroxypropyl-beta cyclodextrin (HP- beta-CD) and randomly methylated-beta cyclodextrin (RAMEB)) have been obtained by applying the following preparation methods: liophylisation, co-precipitation followed by filtration of the end-product and kneading method. The inclusion complexes were characterized by means of Nuclear Magnetic Resonance ((1)H-NMR, (13)C-NMR), Differential Scanning Calorimetry (DSC) and Infrared Spectroscopy (FT-IR). The results obtained confirmed the inclusion of repaglinide into the cyclodextrins cavity.