Scalarane sesterterpenes from Thorectidae sponges as inhibitors of TDP-43 nuclear factor

被引：16

作者：

Festa, Carmen ^{[1
]}

Cassiano, Chiara ^{[2
]}

D'Auria, Maria Valeria ^{[1
]}

Debitus, Cecile ^{[3
]}

Monti, Maria Chiara ^{[2
]}

De Marino, Simona ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy

[2] Univ Salerno, Dept Pharm, I-84084 Fisciano, SA, Italy

[3] IRD, Polynesian Res Ctr Isl Biodivers, F-98713 Papeete, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 43期

关键词：

MARINE SPONGE; CYTOTOXIC SESTERTERPENES; ANTINEOPLASTIC AGENTS; HETERONEMIN; PYRROLOTERPENE;

D O I：

10.1039/c4ob01510j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The analysis of two Thorectidae sponge samples, Hyrtios sp. and Petrosaspongia sp., collected at Fiji Islands, led to the isolation of five new scalarane derivatives along with fifteen known compounds. Their structures were elucidated on the basis of NMR and MS spectroscopic data. The small library of natural scalarane derivatives was investigated for their ability to modulate the activity of trans-activation response DNA-binding protein of 43 kDa (TDP-43), a key factor in several neurodegenerative conditions and the study resulted in the identification of potent inhibitors of TDP-43 protein.

引用

页码：8646 / 8655

页数：10

共 50 条

[21] Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons
Liu, Elaine Y.
Russ, Jenny
Cali, Christopher P.
Phan, Jessica M.
Amlie-Wolf, Alexandre
Lee, Edward B.
CELL REPORTS, 2019, 27 (05): : 1409 - +
[22] Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export
Duan, Lauren
Zaepfel, Benjamin L.
Aksenova, Vasilisa
Dasso, Mary
Rothstein, Jeffrey D.
Kalab, Petr
Hayes, Lindsey R.
CELL REPORTS, 2022, 40 (03):
[23] TDP-43: From Alzheimer's Disease to Limbic-Predominant Age-Related TDP-43 Encephalopathy
Huang, Wendi
Zhou, Yongjian
Tu, Lin
Ba, Zhisheng
Huang, Juan
Huang, Nanqu
Luo, Yong
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2020, 13
[24] Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs
Suzuki, Hiroaki
Shibagaki, Yoshio
Hattori, Seisuke
Matsuoka, Masaaki
HUMAN MOLECULAR GENETICS, 2015, 24 (06) : 1513 - 1527
[25] Inclusion Body Myositis is a TDP-43 Proteinopathy with Nuclear Pore Disruption
Ikenaga, Chiseko
Wilson, Andrew
Wong, Phil
Lloyd, Thomas
ANNALS OF NEUROLOGY, 2023, 94 : S255 - S255
[26] Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping
Buratti, E
Dörk, T
Zuccato, E
Pagani, F
Romano, M
Baralle, FE
EMBO JOURNAL, 2001, 20 (07): : 1774 - 1784
[27] Structural and functional characterization of aggregates from purified TDP-43: a novel approach for understanding TDP-43 aggregate effects in cells
Ermini, E.
Marzi, I.
Cecchi, C.
Cascella, R.
Chiti, F.
FEBS OPEN BIO, 2024, 14 : 357 - 357
[28] Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization
Emile S. Pinarbasi
Tolga Cağatay
Ho Yee Joyce Fung
Ying C. Li
Yuh Min Chook
Philip J. Thomas
Scientific Reports, 8
[29] Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization
Pinarbasi, Emile S.
Cagatay, Tolga
Fung, Ho Yee Joyce
Li, Ying C.
Chook, Yuh Min
Thomas, Philip J.
SCIENTIFIC REPORTS, 2018, 8
[30] Development of TDP-43 inhibitors for treating ALS, FTD, and Alzheimer's disease
Zhang, Chengliang
MUSCLE & NERVE, 2023, 68 : S70 - S70

← 1 2 3 4 5 →