Scalarane sesterterpenes from Thorectidae sponges as inhibitors of TDP-43 nuclear factor

被引：16

作者：

Festa, Carmen ^{[1
]}

Cassiano, Chiara ^{[2
]}

D'Auria, Maria Valeria ^{[1
]}

Debitus, Cecile ^{[3
]}

Monti, Maria Chiara ^{[2
]}

De Marino, Simona ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy

[2] Univ Salerno, Dept Pharm, I-84084 Fisciano, SA, Italy

[3] IRD, Polynesian Res Ctr Isl Biodivers, F-98713 Papeete, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 43期

关键词：

MARINE SPONGE; CYTOTOXIC SESTERTERPENES; ANTINEOPLASTIC AGENTS; HETERONEMIN; PYRROLOTERPENE;

D O I：

10.1039/c4ob01510j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The analysis of two Thorectidae sponge samples, Hyrtios sp. and Petrosaspongia sp., collected at Fiji Islands, led to the isolation of five new scalarane derivatives along with fifteen known compounds. Their structures were elucidated on the basis of NMR and MS spectroscopic data. The small library of natural scalarane derivatives was investigated for their ability to modulate the activity of trans-activation response DNA-binding protein of 43 kDa (TDP-43), a key factor in several neurodegenerative conditions and the study resulted in the identification of potent inhibitors of TDP-43 protein.

引用

页码：8646 / 8655

页数：10

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