Isolation of Two New Prenylflavonols from Epimedium brevicornum and their Effects on Cytokine Production in vitro

被引：30

作者：

Luo, Guo-Jun ^{[1
]}

Ci, Xin-Xin ^{[2
]}

Ren, Rong ^{[1
]}

Wu, Zhao-Yuan ^{[1
]}

Li, Hong-Mei ^{[1
]}

Li, Hai-Zhou ^{[1
]}

Li, Rong-Tao ^{[1
]}

Deng, Xu-Ming ^{[1
,2
]}

机构：

[1] Kunming Univ Sci & Technol, Coll Life Sci & Technol, Kunming 650224, Yunnan, Peoples R China

[2] Jilin Univ, Dept Vet Pharmacol, Coll Anim Sci & Vet Med, Changchun 130023, Jilin, Peoples R China

来源：

PLANTA MEDICA | 2009年 / 75卷 / 08期

基金：

芬兰科学院; 中国国家自然科学基金;

关键词：

Epimedium brevicornum; Berberidaceae; prenylflavonol; anti-inflammatory; biogenetic relationship; FUNGAL METABOLISM; RELEASE; ENDOTOXEMIA; FLAVONOIDS; ICARIIN; ROOTS; CELLS;

D O I：

10.1055/s-0029-1185376

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In an attempt to search for bioactive natural products, two new prenylflavonols, 2"-hydroxy-3"-en-anhydroicaritin (1) and 2"-hydroxy-beta-anhydroicaritin (2), were isolated from the Chinese medicinal herb Epimedium brevicornum. Their structures were determined by 1D and 2D NMR spectroscopic analysis. The effects of compounds 1 and 2 on cytokine production ill vitro were investigated. Compound I could significantly downregulate tumor necrosis factor-alpha (TNF-alpha) production and increase interleukin-10 (IL-10) production. These results suggested that compound 1 may have anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated mouse macrophages. In addition, the biogenetic relationships among compounds 1 and 2 are discussed.

引用

页码：843 / 847

页数：5

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