Isolation of Two New Prenylflavonols from Epimedium brevicornum and their Effects on Cytokine Production in vitro

被引：30
|
作者：
Luo, Guo-Jun [1 ]
Ci, Xin-Xin [2 ]
Ren, Rong [1 ]
Wu, Zhao-Yuan [1 ]
Li, Hong-Mei [1 ]
Li, Hai-Zhou [1 ]
Li, Rong-Tao [1 ]
Deng, Xu-Ming [1 ,2 ]
机构：
[1] Kunming Univ Sci & Technol, Coll Life Sci & Technol, Kunming 650224, Yunnan, Peoples R China
[2] Jilin Univ, Dept Vet Pharmacol, Coll Anim Sci & Vet Med, Changchun 130023, Jilin, Peoples R China
来源：
PLANTA MEDICA | 2009年 / 75卷 / 08期
基金：
芬兰科学院; 中国国家自然科学基金;
关键词：
Epimedium brevicornum; Berberidaceae; prenylflavonol; anti-inflammatory; biogenetic relationship; FUNGAL METABOLISM; RELEASE; ENDOTOXEMIA; FLAVONOIDS; ICARIIN; ROOTS; CELLS;
D O I：
10.1055/s-0029-1185376
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
In an attempt to search for bioactive natural products, two new prenylflavonols, 2"-hydroxy-3"-en-anhydroicaritin (1) and 2"-hydroxy-beta-anhydroicaritin (2), were isolated from the Chinese medicinal herb Epimedium brevicornum. Their structures were determined by 1D and 2D NMR spectroscopic analysis. The effects of compounds 1 and 2 on cytokine production ill vitro were investigated. Compound I could significantly downregulate tumor necrosis factor-alpha (TNF-alpha) production and increase interleukin-10 (IL-10) production. These results suggested that compound 1 may have anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated mouse macrophages. In addition, the biogenetic relationships among compounds 1 and 2 are discussed.
引用
收藏
页码：843 / 847
页数：5
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