Life without the mitochondrial calcium uniporter

被引：17
|
作者：
Herzig, Sebastien [1 ]
Maundrell, Kinsey [1 ]
Martinou, Jean-Claude [1 ]
机构：
[1] Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland
来源：
NATURE CELL BIOLOGY | 2013年 / 15卷 / 12期
关键词：
PERMEABILITY TRANSITION; CELL-DEATH; MCU;
D O I：
10.1038/ncb2891
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Calcium enters mitochondria through a dedicated channel referred to as the mitochondrial calcium uniporter (MCU), whose molecular identity has long remained elusive. Since the discovery of the gene encoding the MCU protein two years ago, researchers have awaited the generation of a mouse lacking the MCU. These mice are fully viable and show defects limited to performance of high-energy-demanding exercises. Strikingly, no protection against necrosis is observed following ischaemiareperfusion in the heart.
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页码：1398 / 1400
页数：3
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