Life without the mitochondrial calcium uniporter

被引：17
|
作者：
Herzig, Sebastien [1 ]
Maundrell, Kinsey [1 ]
Martinou, Jean-Claude [1 ]
机构：
[1] Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland
来源：
NATURE CELL BIOLOGY | 2013年 / 15卷 / 12期
关键词：
PERMEABILITY TRANSITION; CELL-DEATH; MCU;
D O I：
10.1038/ncb2891
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Calcium enters mitochondria through a dedicated channel referred to as the mitochondrial calcium uniporter (MCU), whose molecular identity has long remained elusive. Since the discovery of the gene encoding the MCU protein two years ago, researchers have awaited the generation of a mouse lacking the MCU. These mice are fully viable and show defects limited to performance of high-energy-demanding exercises. Strikingly, no protection against necrosis is observed following ischaemiareperfusion in the heart.
引用
下载
收藏
页码：1398 / 1400
页数：3
相关论文
共 50 条
  • [41] Emre Regulates the Mitochondrial Calcium Uniporter in vivo
    Liu, Julia C.
    Syder, Nicole
    Ghorashi, Nima
    Willingham, Thomas B.
    Parks, Randi J.
    Sun, Junhui
    Fergusson, Maria
    Liu, Jie
    Holmstrom, Kira M.
    Menazza, Sara
    Springer, Danielle
    Liu, Chengyu
    Glancy, Brian
    Finkel, Toren
    Murphy, Elizabeth
    CIRCULATION RESEARCH, 2020, 127
  • [42] INHIBITING THE MITOCHONDRIAL CALCIUM UNIPORTER INCREASE SYSTOLIC CALCIUM AND INDUCES UNSOLICITED CALCIUM WAVES WITHOUT AFFECTING SARCOPLASMIC RETICULUM CALCIUM CONTENT
    Oropeza, Yuriana
    Bernal-Ramirez, Judith
    Reyes-Alvarez, Eduardo
    Garza-Lopez, Jesus
    Garcia-Rivas, Gerardo
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2017, 69 (11) : 421 - 421
  • [43] The Mitochondrial Calcium Uniporter Regulates Hepatic Lipid Accumulation and Mitochondrial Oxidation
    Lamoia, Traci E.
    Hubbard, Brandon T.
    Guerra, Mateus
    Goodman, Russell
    Nathanson, Michael H.
    Mootha, Vamsi
    Shulman, Gerald I.
    DIABETES, 2022, 71
  • [44] EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex
    Sancak, Yasemin
    Markhard, Andrew L.
    Kitami, Toshimori
    Kovacs-Bogdan, Erika
    Kamer, Kimberli J.
    Udeshi, Namrata D.
    Carr, Steven A.
    Chaudhuri, Dipayan
    Clapham, David E.
    Li, Andrew A.
    Calvo, Sarah E.
    Goldberger, Olga
    Mootha, Vamsi K.
    SCIENCE, 2013, 342 (6164) : 1379 - 1382
  • [45] Effect of mitochondrial calcium uniporter blocking on human spermatozoa
    Bravo, A.
    Treulen, F.
    Uribe, P.
    Boguen, R.
    Felmer, R.
    Villegas, J. V.
    ANDROLOGIA, 2015, 47 (06) : 662 - 668
  • [46] Novel Approach for The Electrophysiological Characterization of Mitochondrial Calcium Uniporter
    Polina, Iuliia
    Xie, An
    Mishra, Jyotsna
    Adhikari, Neeta
    Clements, Richard
    Jhun, Bong Sook
    Dudley, Samuel, Jr.
    O-Uchi, Jin
    FASEB JOURNAL, 2021, 35
  • [47] Cryo-EM Structure of a Mitochondrial Calcium Uniporter
    Yoo, Jiho
    Wu, Mengyu
    Yin, Ying
    Herzik, Mark A., Jr.
    Lander, Gabriel C.
    Lee, Seok-Yong
    BIOPHYSICAL JOURNAL, 2019, 116 (03) : 53A - 53A
  • [48] The role of the mitochondrial calcium uniporter (MCU) complex in cancer
    Adina Vultur
    Christine S. Gibhardt
    Hedwig Stanisz
    Ivan Bogeski
    Pflügers Archiv - European Journal of Physiology, 2018, 470 : 1149 - 1163
  • [49] Mechanisms of ion selectivity and throughput in the mitochondrial calcium uniporter
    Delgado, Bryce D.
    Long, Stephen B.
    SCIENCE ADVANCES, 2022, 8 (50):
  • [50] Molecular structure and pathophysiological roles of the Mitochondrial Calcium Uniporter
    Mammucari, Cristina
    Raffaello, Anna
    Reane, Denis Vecellio
    Rizzuto, Rosario
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2016, 1863 (10): : 2457 - 2464
12345