Architecture of the mitochondrial calcium uniporter

被引：0
|
作者：
Kirill Oxenoid
Ying Dong
Chan Cao
Tanxing Cui
Yasemin Sancak
Andrew L. Markhard
Zenon Grabarek
Liangliang Kong
Zhijun Liu
Bo Ouyang
Yao Cong
Vamsi K. Mootha
James J. Chou
机构：
[1] Harvard Medical School,Department of Biological Chemistry and Molecular Pharmacology
[2] State Key Laboratory of Molecular Biology,Department of Molecular Biology and Howard Hughes Medical Institute
[3] National Center for Protein Science Shanghai,undefined
[4] Shanghai Institute of Biochemistry and Cell Biology,undefined
[5] Shanghai Science Research Center,undefined
[6] Chinese Academy of Sciences,undefined
[7] State Key Laboratory of Elemento-Organic Chemistry and College of Chemistry,undefined
[8] Nankai University,undefined
[9] Massachusetts General Hospital,undefined
来源：
Nature | 2016年 / 533卷
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摘要：
The structure of the core region of the mitochondrial calcium uniporter (MCU) is determined by NMR and electron microscopy, revealing that MCU is a homo-pentamer with a specific transmembrane helix forming a hydrophilic pore across the membrane, and representing one of the largest membrane protein structures characterized by NMR spectroscopy.
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页码：269 / 273
页数：4
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