Long Non-Coding RNAs and Complex Human Diseases

被引：166
|
作者：
Li, Jing [1 ]
Xuan, Zhenyu [2 ]
Liu, Changning [1 ]
机构：
[1] Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Bioinformat Res Grp,Adv Comp Res Ctr, Beijing 100190, Peoples R China
[2] Univ Texas Dallas, Ctr Syst Biol, Dept Mol & Cell Biol, Richardson, TX 75080 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 09期
基金：
中国国家自然科学基金;
关键词：
non-coding RNA; long non-coding RNA; complex human disease; GENOME-WIDE ASSOCIATION; GENE-ENVIRONMENT INTERACTIONS; CORONARY-ARTERY-DISEASE; PROSTATE-SPECIFIC GENE; PROTEIN-CODING RNA; ULTRACONSERVED ELEMENTS; ANTISENSE TRANSCRIPT; BC200; RNA; INTEGRATIVE ANNOTATION; TREMOR/ATAXIA SYNDROME;
D O I：
10.3390/ijms140918790
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Long non-coding RNAs (lncRNAs) are a heterogeneous class of RNAs that are generally defined as non-protein-coding transcripts longer than 200 nucleotides. Recently, an increasing number of studies have shown that lncRNAs can be involved in various critical biological processes, such as chromatin remodeling, gene transcription, and protein transport and trafficking. Moreover, lncRNAs are dysregulated in a number of complex human diseases, including coronary artery diseases, autoimmune diseases, neurological disorders, and various cancers, which indicates their important roles in these diseases. Here, we reviewed the current understanding of lncRNAs, including their definition and subclassification, regulatory functions, and potential roles in different types of complex human diseases.
引用
收藏
页码：18790 / 18808
页数：19
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