Long non-coding RNAs and splicing

被引：8
|
作者：
Stanek, David [1 ]
机构：
[1] Czech Acad Sci, Inst Mol Genet, Prague, Czech Republic
来源：
NON-CODING GENOME | 2021年 / 65卷 / 04期
关键词：
MESSENGER-RNA; GENE-EXPRESSION; EVOLUTION; TRANSCRIPTION; INTRONS; GENOME; INEFFICIENT; RECRUITMENT; SELECTION; PATTERNS;
D O I：
10.1042/EBC20200087
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review I focus on the role of splicing in long non-coding RNA (lncRNA) life. First, I summarize differences between the splicing efficiency of protein-coding genes and lncRNAs and discuss why non-coding RNAs are spliced less efficiently. In the second half of the review, I speculate why splice sites are the most conserved sequences in lncRNAs and what additional roles could splicing play in lncRNA metabolism. I discuss the hypothesis that the splicing machinery can, besides its dominant role in intron removal and exon joining, protect cells from undesired transcripts.
引用
收藏
页码：723 / 729
页数：7
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