Synthesis of Novel 3-Aryl-5-dichloromethyl-Δ2-1,2,4-oxadiazolines

被引：0

作者：

Guirado, Antonio ^{[1
]}

Sandoval, Jose A. ^{[1
]}

Alarcon, Enrique ^{[1
]}

Vera, Maria ^{[1
]}

Bautista, Delia ^{[1
]}

Galvez, Jesus ^{[2
]}

机构：

[1] Univ Murcia, Fac Quim, Dept Quim Organ, Campus Espinardo, Murcia 3100, Spain

[2] Univ Murcia, Fac Quim, Dept Quim Fis, Campus Espinardo, Murcia 3100, Spain

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2019年 / 56卷 / 06期

关键词：

MECHANISM-BASED INACTIVATORS; AROMATIC-ALDEHYDES; NITRILE OXIDE; REDUCTION; 4,5-DIHYDRO-1,2,4-OXADIAZOLES; TRICHLOROMETHYL; CYCLOADDITION;

D O I：

10.1002/jhet.3558

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthetic approach to hitherto unknown 3-aryl-5-dichloromethyl-Delta(2)-1,2,4-oxadiazolines, of synthetic and biological interest, has been developed involving high-yield reactions between N-(2,2-dichlorovinyl)benzimidoyl chlorides and hydroxylamine. The molecular structure of one member of this new family of compounds-5-dichloromethyl-3-(4-fluorophenyl)-1,2,4-oxadiazoline-has been determined by X-ray crystallography. Density functional theory calculations supporting the proposed reaction pathway for the formation of these products have been carried out.

引用

页码：1873 / 1878

页数：6

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