Synthesis of isoxazolyl substituted 1,2,4-oxadiazolines and pyrazolines

被引：0

作者：

Geng, L ^{[1
]}

Lei, M ^{[1
]}

Wang, YG ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 25卷 / 06期

关键词：

1,3-dipolar cycloaddition; nitrile oxide; 1,2,4-oxadiazoline; pyrazoline;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile method for preparation of 5-methyl-5-[5-(tert-butyldimethylsiloxymethyl)-3-isoxazolyl]-3-aryl-4-(4-methyloxyphenyl)-4,5-dihydro-1,2,4-oxadiazoles (4a similar to 4e) via 1,3-dipolar cycloaddition of Schiff bases derived from 3-acetyl-5-hydroxymethylisoxazoles and nitrile oxides in situ generated from oximes was described. 5-(tert-Butyldimethylsiloxymethyl)-3-(1,5-diaryl-4,5-dihydropyrazol-3-yl)isoxazoles (6a similar to 6i) were also prepared through cycloaddition of aryl hydrazine and alpha,beta-unsaturated ketones (5) derived from 3-acetyl-5-hydroxylmethylisoxazoles. The structures of all new compounds were characterized by H-1 NMR, C-13 NMR, MS, IR and HRMS spectra.

引用

页码：690 / 695

页数：6

共 30 条

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