IL-17A AND IL-17F ARE SECRETED BY ENTHESIS T CELLS AND SYNERGIZE WITH TNF TO INDUCE CCL20 FROM ENTHESEAL STROMAL CELLS

被引:1
|
作者
Bridgewood, Charlie [1 ]
Russell, Tobias [1 ]
Watad, Abdulla [2 ,3 ]
Rowe, Hannah [1 ]
Zhou, Qiao [1 ]
Khan, Almas [4 ]
Loughenbury, Peter [4 ]
Rao, Abhay S. [4 ]
Millner, Peter [4 ]
Dunsmuir, Robert [4 ]
Cuthbert, Richard [1 ]
Mcgonagle, Dennis [1 ]
机构
[1] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England
[2] Sheba Med Ctr, Dept Med B, Zabludowicz Ctr Autoimmune Dis, Tel Hashomer, Israel
[3] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
[4] Leeds Teaching Hosp NHS Trust, Leeds, W Yorkshire, England
关键词
D O I
10.1136/annrheumdis-2019-eular.3527
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
THU0013
引用
收藏
页码:274 / 274
页数:1
相关论文
共 50 条
  • [41] Bimekizumab Blocks T Cell-Mediated Osteogenic Differentiation of Periosteal Stem Cells: Coupling Pathological Bone Formation to IL-17A and IL-17F Signaling
    Shah, Mittal
    Maroof, Ash
    Al-Hosni, Rawiya
    Gikas, Panagiotis
    Gozzard, Neil
    Shaw, Stevan
    Roberts, Scott
    ARTHRITIS & RHEUMATOLOGY, 2017, 69
  • [42] The Pro-inflammatory Cytokines IL-17A, IL-17F and TNF-alpha Significantly Contribute to the Psoriatic Gene Signature in the Skin
    Trigona, Wendy
    Morehouse, Christopher
    Strange, Christina
    Kohut, Nancy
    Phipps, Sandrina
    Wilson, Susan
    Yao, Yihong
    White, Barbara
    Rosko, Lorin
    Jallal, Bahija
    White, Wendy
    CLINICAL IMMUNOLOGY, 2009, 131 : S19 - S19
  • [43] Influence of IL10 (rs1800896) Polymorphism and TNF-α, IL-10, IL-17A, and IL-17F Serum Levels in Ankylosing Spondylitis
    Braga, Matheus
    Lara-Armi, Fernanda Formaggi
    Neves, Janisleya Silva Ferreira
    Rocha-Loures, Marco Antonio
    Terron-Monich, Mariana de Souza
    Bahls-Pinto, Larissa Danielle
    de Lima Neto, Quirino Alves
    Zacarias, Joana Maira Valentini
    Sell, Ana Maria
    Visentainer, Jeane Eliete Laguila
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [44] ACTIVATED STROMAL CELLS INDUCE CCL20 RELEASE AND T CELL MIGRATION
    Cafaro, G.
    Garcia-Melchor, E.
    Akbar, M.
    Gilchrist, D. S.
    Kitson, S. M.
    Siebert, S.
    Millar, N. L.
    McInnes, I. B.
    ANNALS OF THE RHEUMATIC DISEASES, 2018, 77 : 1216 - 1216
  • [45] 雄激素对体外分化Th17细胞IL-17a、IL-17f、RORγt表达的影响
    刘双
    阳慧芝
    曾涛
    杨姗姗
    张方
    陈嵘祎
    中国皮肤性病学杂志, 2018, 32 (01) : 22 - 25
  • [46] Potentiating Effects Of IL-17A, IL-17AF, IL-17F In Combination With TNF But Not With IL-1beta In Human Primary Fibroblast-Like Synoviocytes From Rheumatoid Arthritis Patients
    Huppertz, Christine
    Djuric, Marija Curcic
    Hennze, Robert
    Raulf, Friedrich
    Kolbinger, Frank
    Mir, Anis
    Lee, David
    ARTHRITIS AND RHEUMATISM, 2013, 65 : S792 - S792
  • [47] A Heterodimeric Cytokine, Consisting of IL-17A and IL-17F, Promotes Migration and Capillary-Like Tube Formation of Human Vascular Endothelial Cells
    Numasaki, Muneo
    Tsukamoto, Hiroki
    Tomioka, Yoshihisa
    Nishioka, Yasuhiko
    Ohrui, Takashi
    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2016, 240 (01): : 47 - 56
  • [48] IL-17 and IL-17F modulate GM-CSF production by lung microvascular endothelial cells stimulated with IL-1β and/or TNF-α
    Numasaki, M
    Tomioka, Y
    Takahashi, H
    Sasaki, H
    IMMUNOLOGY LETTERS, 2004, 95 (02) : 175 - 184
  • [49] Serum CCL20 combined with IL-17A as early diagnostic and prognostic biomarkers for human colorectal cancer
    Wang, Dan
    Yuan, Weitang
    Wang, Yaping
    Wu, Qian
    Yang, Li
    Li, Feng
    Chen, Xinfeng
    Zhang, Zhen
    Yu, Weina
    Maimela, Nomathamsanqa Resegofetse
    Cao, Ling
    Wang, Dong
    Wang, Junxia
    Sun, Zhenqiang
    Liu, Jinbo
    Zhang, Yi
    JOURNAL OF TRANSLATIONAL MEDICINE, 2019, 17 (01)
  • [50] Developmental Regulation of CCL20 by IL-17A in Airway Epithelium: Role of miRNA 361 and miRNA 21
    Miller, L. A.
    Gerriets, J. E.
    Postlethwait, E. M.
    Hyde, D. M.
    Wu, R.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179