IL-17A AND IL-17F ARE SECRETED BY ENTHESIS T CELLS AND SYNERGIZE WITH TNF TO INDUCE CCL20 FROM ENTHESEAL STROMAL CELLS

被引：1
|
作者：
Bridgewood, Charlie [1 ]
Russell, Tobias [1 ]
Watad, Abdulla [2 ,3 ]
Rowe, Hannah [1 ]
Zhou, Qiao [1 ]
Khan, Almas [4 ]
Loughenbury, Peter [4 ]
Rao, Abhay S. [4 ]
Millner, Peter [4 ]
Dunsmuir, Robert [4 ]
Cuthbert, Richard [1 ]
Mcgonagle, Dennis [1 ]
机构：
[1] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England
[2] Sheba Med Ctr, Dept Med B, Zabludowicz Ctr Autoimmune Dis, Tel Hashomer, Israel
[3] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
[4] Leeds Teaching Hosp NHS Trust, Leeds, W Yorkshire, England
来源：
ANNALS OF THE RHEUMATIC DISEASES | 2019年 / 78卷
关键词：
D O I：
10.1136/annrheumdis-2019-eular.3527
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
THU0013
引用
收藏
页码：274 / 274
页数：1
相关论文
共 50 条
  • [31] T Cell-Derived IL-17A and IL-17F Drive Bone Formation from Human Periosteal Stem Cells: Implications for Enthesophyte Formation.
    Shah, Mittal
    Maroof, Ash
    Al-Hosni, Rawiya
    Gikas, Panagiotis
    Gozzard, Neil
    Shaw, Stevan
    Roberts, Scott
    JOURNAL OF BONE AND MINERAL RESEARCH, 2017, 32 : S196 - S196
  • [32] Vidofludimus Induces p53-Mediated Apoptosis in Activated T Cells and Inhibits IL-17A and IL-17F Expression Decoupled From Lymphocyte Proliferation
    Hamm, Svetlana
    Henning, Stefan W.
    Hentsch, Bernd
    Vitt, Daniel
    Groeppel, Manfred
    Ammendola, Aldo
    GASTROENTEROLOGY, 2012, 142 (05) : S867 - S867
  • [33] INTERFERON GAMMA PROTECTS MICE FROM CNS AUTOIMMUNITY ALSO IN THE ABSENCE OF IL-17A AND IL-17F
    Regen, T.
    Huppert, J.
    Yogev, N.
    Prinz, I.
    Waisman, A.
    GLIA, 2013, 61 : S170 - S171
  • [34] Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota
    Ce Tang
    Shigeru Kakuta
    Kenji Shimizu
    Motohiko Kadoki
    Tomonori Kamiya
    Tomoyuki Shimazu
    Sachiko Kubo
    Shinobu Saijo
    Harumichi Ishigame
    Susumu Nakae
    Yoichiro Iwakura
    Nature Immunology, 2018, 19 : 755 - 765
  • [35] Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota
    Tang, C.
    Kakuta, S.
    Iwakura, Y.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 1353 - 1353
  • [36] Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells
    Shah, Mittal
    Maroof, Asher
    Gikas, Panos
    Mittal, Gayatri
    Keen, Richard
    Baeten, Dominique
    Shaw, Stevan
    Roberts, Scott J.
    RMD OPEN, 2020, 6 (02):
  • [37] Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota
    Tang, Ce
    Kakuta, Shigeru
    Shimizu, Kenji
    Kadoki, Motohiko
    Kamiya, Tomonori
    Shimazu, Tomoyuki
    Kubo, Sachiko
    Saijo, Shinobu
    Ishigame, Harumichi
    Nakae, Susumu
    Iwakura, Yoichiro
    NATURE IMMUNOLOGY, 2018, 19 (07) : 755 - +
  • [38] Interferon gamma protects mice from CNS autoimmunity also in the absence of IL-17A and IL-17F
    Regen, T.
    Huppert, J.
    Yogev, N.
    Prinz, I.
    Waisman, A.
    IMMUNOLOGY, 2012, 137 : 355 - 355
  • [39] CYTOMETRIC ANALYSIS OF ACTIVATED ENTHESEAL TISSUE RESIDENT T-CELLS REVEALS IL-17F AS THE DOMINANT IL-17 ISOFORM EXPRESSED BY INNATE AND ADAPTIVE LYMPHOCYTES
    Mcdermott, N.
    Macleod, T.
    Rao, A. S.
    Borse, V.
    Loughenbury, P.
    Dunsmuir, R.
    Khan, A.
    Maroof, A.
    Mcgonagle, D.
    ANNALS OF THE RHEUMATIC DISEASES, 2023, 82 : 1184 - 1185
  • [40] IL-17A versus IL-17F induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in AGS gastric adenocarcinoma cells
    Zhou, Yuan
    Toh, Myew-Ling
    Zrioual, Saloua
    Miossec, Pierre
    CYTOKINE, 2007, 38 (03) : 157 - 164
12345