Sinulaflexiolide P, A Cembrane-Type Diterpenoid from Bornean Soft Coral Sinularia flexibilis

被引：7
|
作者：
Phan, Chin-Soon [1 ]
Yee, Chun-Sieng [1 ]
Vairappan, Charles Santhanaraju [1 ]
Ishii, Takahiro [2 ]
Kamada, Takashi [3 ]
机构：
[1] Univ Malaysia Sabah, Inst Trop Biol & Conservat, Kota Kinabalu 88400, Sabah, Malaysia
[2] Univ Ryukyus, Fac Agr, Dept Biosci & Biotechnol, 1 Senbaru, Nishihara, Okinawa 9030213, Japan
[3] Shizuoka Inst Sci & Technol, Fac Sci & Technol, Dept Mat & Life Sci, 2200-2 Toyosawa, Shizuoka 4378555, Japan
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2019年 / 55卷 / 02期
关键词：
Sinularia flexibilis; soft coral; diterpenoid; cembrane; antifungal; SARCOPHYTON-TROCHELIOPHORUM; SESQUITERPENOIDS; TERPENOIDS;
D O I：
10.1007/s10600-019-02668-w
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new cembrane-type diterpenoid, sinulaflexiolide P (1), along with three known derivatives: sinulaflexiolide H (2), 11-epi-sinulariolide acetate (3), and (1S*,3S*,4S*,7E,11E)-3,4-epoxy-13-oxo-3,7,11,15-cembratriene (4), was isolated from a population of Bornean soft coral Sinularia flexibilis. The structures of these metabolites were elucidated based on spectroscopic data including NMR and HR-ESI-MS. In addition, these compounds were tested against six strains of marine fungi.
引用
收藏
页码：285 / 288
页数：4
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