Sinulaflexiolide P, A Cembrane-Type Diterpenoid from Bornean Soft Coral Sinularia flexibilis

被引：7
|
作者：
Phan, Chin-Soon [1 ]
Yee, Chun-Sieng [1 ]
Vairappan, Charles Santhanaraju [1 ]
Ishii, Takahiro [2 ]
Kamada, Takashi [3 ]
机构：
[1] Univ Malaysia Sabah, Inst Trop Biol & Conservat, Kota Kinabalu 88400, Sabah, Malaysia
[2] Univ Ryukyus, Fac Agr, Dept Biosci & Biotechnol, 1 Senbaru, Nishihara, Okinawa 9030213, Japan
[3] Shizuoka Inst Sci & Technol, Fac Sci & Technol, Dept Mat & Life Sci, 2200-2 Toyosawa, Shizuoka 4378555, Japan
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2019年 / 55卷 / 02期
关键词：
Sinularia flexibilis; soft coral; diterpenoid; cembrane; antifungal; SARCOPHYTON-TROCHELIOPHORUM; SESQUITERPENOIDS; TERPENOIDS;
D O I：
10.1007/s10600-019-02668-w
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new cembrane-type diterpenoid, sinulaflexiolide P (1), along with three known derivatives: sinulaflexiolide H (2), 11-epi-sinulariolide acetate (3), and (1S*,3S*,4S*,7E,11E)-3,4-epoxy-13-oxo-3,7,11,15-cembratriene (4), was isolated from a population of Bornean soft coral Sinularia flexibilis. The structures of these metabolites were elucidated based on spectroscopic data including NMR and HR-ESI-MS. In addition, these compounds were tested against six strains of marine fungi.
引用
收藏
页码：285 / 288
页数：4
相关论文
共 50 条
  • [1] Sinulaflexiolide P, A Cembrane-Type Diterpenoid from Bornean Soft Coral Sinularia flexibilis
    Chin-Soon Phan
    Chun-Sieng Yee
    Charles Santhanaraju Vairappan
    Takahiro Ishii
    Takashi Kamada
    Chemistry of Natural Compounds, 2019, 55 : 285 - 288
  • [2] Sinulaflexiolides A-K, cembrane-type diterpenoids from the Chinese soft coral Sinularia flexibilis
    Wen, Ting
    Ding, Yi
    Deng, Zhiwei
    van Ofwegen, Leen P.
    Proksch, Peter
    Lin, Wenhan
    JOURNAL OF NATURAL PRODUCTS, 2008, 71 (07): : 1133 - 1140
  • [3] Flexibilins A-C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis
    Hu, Li-Chung
    Su, Jui-Hsin
    Chiang, Michael Yen-Nan
    Lu, Mei-Chin
    Hwang, Tsong-Long
    Chen, Yung-Husan
    Hu, Wan-Ping
    Lin, Nai-Cheng
    Wang, Wei-Hsien
    Fang, Lee-Shing
    Kuo, Yueh-Hsiung
    Sung, Ping-Jyun
    MARINE DRUGS, 2013, 11 (06): : 1999 - 2012
  • [4] Cembrane diterpenoids from the Taiwanese soft coral Sinularia flexibilis
    Lin, Yun-Sheng
    Chen, Chung-Hsiung
    Liaw, Chia-Ching
    Chen, Yu-Chen
    Kuo, Yao-Haur
    Shen, Ya-Ching
    TETRAHEDRON, 2009, 65 (45) : 9157 - 9164
  • [5] NEW CEMBRANE-TYPE DITERPENOIDS FROM THE OKINAWAN SOFT CORAL SINULARIA SP
    IGUCHI, K
    SHIMURA, H
    YAMADA, Y
    JOURNAL OF NATURAL PRODUCTS, 1992, 55 (12): : 1779 - 1782
  • [6] New Cembrane Diterpenes from Taiwanese Soft Coral Sinularia flexibilis
    Lo, Kuang-Liang
    Khalil, Ashraf Taha
    Chen, Meng-Hsien
    Shen, Ya-Ching
    HELVETICA CHIMICA ACTA, 2010, 93 (07) : 1329 - 1335
  • [7] Cytotoxic and Antifungal Terpenoids from Bornean Soft Coral, Sinularia flexibilis
    Kamada, Takashi
    Phan, Chin-Soon
    Hamada, Toshiyuki
    Hatai, Kishio
    Vairappan, Charles Santhanaraju
    NATURAL PRODUCT COMMUNICATIONS, 2018, 13 (01) : 17 - 19
  • [8] A new cembrane-type diterpenoid from Bornean liverwort Chandonanthus hirtellus
    Ng, Shean-Yeaw
    Kamada, Takashi
    Suleiman, Monica
    Vairappan, Charles S.
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2016, 18 (07) : 690 - 696
  • [9] Isolation and identification of a novel cembrane-type diterpenoid from the soft coral Sarcophyton crassocaule
    Xu, XH
    Kong, CH
    Lin, CJ
    Wang, X
    Lu, JH
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2003, 24 (06): : 1023 - 1025
  • [10] Iso-ximaonanolobatin G, a minor new cembrane-type diterpenoid from the South China Sea soft coral Sinularia nanolobata
    Lin, Na
    Wang, Hong
    Guo, Yue-Wei
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2022, 24 (06) : 589 - 595
12345