Peptides Restore Functional State of the Kidneys During Cisplatin-Induced Acute Renal Failure

被引：8

作者：

Zamorskii, I. I. ^{[1
]}

Shchudrova, T. S. ^{[1
]}

Lin'kova, N. S. ^{[3
,4
]}

Nichik, T. E. ^{[4
]}

Khavinson, V. Kh. ^{[2
,3
]}

机构：

[1] Bukovinian State Med Univ, Chernovtsy, Ukraine

[2] II Mechnikov North Western State Med Univ, St Petersburg, Russia

[3] St Petersburg State Polytech Univ, St Petersburg, Russia

[4] St Petersburg Inst Bioregulat & Gerontol, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 159卷 / 06期

关键词：

acute renal failure; cisplatin; peptides; NEPHROTOXICITY; MECHANISMS;

D O I：

10.1007/s10517-015-3062-y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of polypeptide complex from the kidney and short peptides AED, EDL, and AEDG on renal functions were studied in rats with cisplatin-induced acute renal failure. AED peptide decreased protein excretion and electrolyte concentration in the urine. Polypeptide complex from the kidney and peptides EDL and AEDG normalized diuresis, creatinine concentration in the urine and its excretion, glomerular filtration rate, and absolute resorption of sodium ions and reduced protein concentration in the urine and its excretion, the concentrations of sodium and potassium ions in the urine, and other parameters. EDL peptide produced was potent nephroprotective effect. It is known that the polypeptide complex of the kidney and short peptides restore the expression of signal molecules (marker of functional state of the kidneys), so these peptide substances can have nephroprotective effect during various renal pathologies.

引用

页码：736 / 739

页数：4

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