Peptides Restore Functional State of the Kidneys During Cisplatin-Induced Acute Renal Failure

被引：8
|
作者：
Zamorskii, I. I. [1 ]
Shchudrova, T. S. [1 ]
Lin'kova, N. S. [3 ,4 ]
Nichik, T. E. [4 ]
Khavinson, V. Kh. [2 ,3 ]
机构：
[1] Bukovinian State Med Univ, Chernovtsy, Ukraine
[2] II Mechnikov North Western State Med Univ, St Petersburg, Russia
[3] St Petersburg State Polytech Univ, St Petersburg, Russia
[4] St Petersburg Inst Bioregulat & Gerontol, St Petersburg, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 159卷 / 06期
关键词：
acute renal failure; cisplatin; peptides; NEPHROTOXICITY; MECHANISMS;
D O I：
10.1007/s10517-015-3062-y
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of polypeptide complex from the kidney and short peptides AED, EDL, and AEDG on renal functions were studied in rats with cisplatin-induced acute renal failure. AED peptide decreased protein excretion and electrolyte concentration in the urine. Polypeptide complex from the kidney and peptides EDL and AEDG normalized diuresis, creatinine concentration in the urine and its excretion, glomerular filtration rate, and absolute resorption of sodium ions and reduced protein concentration in the urine and its excretion, the concentrations of sodium and potassium ions in the urine, and other parameters. EDL peptide produced was potent nephroprotective effect. It is known that the polypeptide complex of the kidney and short peptides restore the expression of signal molecules (marker of functional state of the kidneys), so these peptide substances can have nephroprotective effect during various renal pathologies.
引用
收藏
页码：736 / 739
页数：4
相关论文
共 50 条
  • [21] Evaluation of Cisplatin-Induced Acute Renal Failure Amelioration Using Fondaparinux and Alteplase
    Abdel-Bakky, Mohamed S.
    Aldakhili, Anas S. A.
    Ali, Hussein M.
    Babiker, Ali Y.
    Alhowail, Ahmad H.
    Mohammed, Salman A. A.
    PHARMACEUTICALS, 2023, 16 (07)
  • [22] ROLE OF VASCULAR CONGESTION IN CISPLATIN-INDUCED ACUTE-RENAL-FAILURE IN THE RAT
    LUKE, DR
    VADIEI, K
    LOPEZBERESTEIN, G
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 1992, 7 (01) : 1 - 7
  • [23] Effect of elevated serum uric acid on cisplatin-induced acute renal failure
    Roncal, Carlos A.
    Mu, Wei
    Croker, Byron
    Reungjui, Sirirat
    Ouyang, Xiaosen
    Tabah-Fisch, Isabelle
    Johnson, Richard J.
    Ejaz, A. Ahsan
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2007, 292 (01) : F116 - F122
  • [24] Erythropoietin enhances recovery after cisplatin-induced acute renal failure in the rat
    Bagnis, C
    Beaufils, H
    Jacquiaud, C
    Adabra, Y
    Jouanneau, C
    Le Nahour, G
    Jaudon, MC
    Bourbouze, R
    Jacobs, C
    Deray, G
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2001, 16 (05) : 932 - 938
  • [25] Salviae radix extract prevents cisplatin-induced acute renal failure in rabbits
    Jeong, JC
    Hwang, WM
    Yoon, CH
    Kim, YK
    NEPHRON, 2001, 88 (03): : 241 - 246
  • [26] Cell cycle progression after cisplatin-induced acute renal failure.
    Price, PM
    Megyesi, J
    Safirstein, RL
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2002, 13 : 546A - 546A
  • [27] PANCASPASE INHIBITION IS PROTECTIVE AGAINST CISPLATIN-INDUCED ACUTE RENAL FAILURE (ARF)
    Faubel, Sarah
    Reznikov, Leonid
    Somerset, Hilary
    Durson, Belda
    Dinarello, Charles A.
    Edelstein, Charles L.
    NEPHROLOGY, 2005, 10 : A275 - A275
  • [28] 6-Gingerol prevents cisplatin-induced acute renal failure in rats
    Kuhad, Anurag
    Tirkey, Naveen
    Pilkhwal, Sangeeta
    Chopra, Kanwaljit
    BIOFACTORS, 2006, 26 (03) : 189 - 200
  • [29] Carotenoid Lutein Protects the Kidney against Cisplatin-Induced Acute Renal Failure
    Sindhu, Edakkadath R.
    Kuttan, Ramadasan
    JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY, 2013, 32 (01) : 21 - 28
  • [30] FATAL PULMONARY BLEOMYCIN TOXICITY IN CISPLATIN-INDUCED ACUTE-RENAL-FAILURE
    BENNETT, WM
    PASTORE, L
    HOUGHTON, DC
    CANCER TREATMENT REPORTS, 1980, 64 (8-9): : 921 - 924
12345