Peptides Restore Functional State of the Kidneys During Cisplatin-Induced Acute Renal Failure

被引：8
|
作者：
Zamorskii, I. I. [1 ]
Shchudrova, T. S. [1 ]
Lin'kova, N. S. [3 ,4 ]
Nichik, T. E. [4 ]
Khavinson, V. Kh. [2 ,3 ]
机构：
[1] Bukovinian State Med Univ, Chernovtsy, Ukraine
[2] II Mechnikov North Western State Med Univ, St Petersburg, Russia
[3] St Petersburg State Polytech Univ, St Petersburg, Russia
[4] St Petersburg Inst Bioregulat & Gerontol, St Petersburg, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 159卷 / 06期
关键词：
acute renal failure; cisplatin; peptides; NEPHROTOXICITY; MECHANISMS;
D O I：
10.1007/s10517-015-3062-y
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of polypeptide complex from the kidney and short peptides AED, EDL, and AEDG on renal functions were studied in rats with cisplatin-induced acute renal failure. AED peptide decreased protein excretion and electrolyte concentration in the urine. Polypeptide complex from the kidney and peptides EDL and AEDG normalized diuresis, creatinine concentration in the urine and its excretion, glomerular filtration rate, and absolute resorption of sodium ions and reduced protein concentration in the urine and its excretion, the concentrations of sodium and potassium ions in the urine, and other parameters. EDL peptide produced was potent nephroprotective effect. It is known that the polypeptide complex of the kidney and short peptides restore the expression of signal molecules (marker of functional state of the kidneys), so these peptide substances can have nephroprotective effect during various renal pathologies.
引用
收藏
页码：736 / 739
页数：4
相关论文
共 50 条
  • [1] Peptides Restore Functional State of the Kidneys During Cisplatin-Induced Acute Renal Failure
    I. I. Zamorskii
    T. S. Shchudrova
    N. S. Lin’kova
    T. E. Nichik
    V. Kh. Khavinson
    Bulletin of Experimental Biology and Medicine, 2015, 159 : 736 - 739
  • [2] Urinary marker for oxidative stress in kidneys in cisplatin-induced acute renal failure in rats
    Zhou, H
    Kato, A
    Miyaji, T
    Yasuda, H
    Fujigaki, Y
    Yamamoto, T
    Yonemura, K
    Takebayashi, S
    Mineta, H
    Hishida, A
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (03) : 616 - 623
  • [3] Effect of erythropoietin on cisplatin-induced acute renal failure.
    Bagnis, C
    Beaufils, H
    Adabra, Y
    Jouanneau, C
    Jacquiaud, C
    Dubois, M
    Jacobs, C
    Deray, G
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1996, 7 (09): : A2956 - A2956
  • [4] MITOCHONDRIAL ALTERATIONS IN CISPLATIN-INDUCED ACUTE-RENAL-FAILURE
    GORDON, JA
    GATTONE, VH
    AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 250 (06): : F991 - F998
  • [5] INFLUENCE OF MONTELUKAST ON CISPLATIN-INDUCED EXPERIMENTAL ACUTE RENAL FAILURE
    Teslariu, Oana
    Nechifor, M.
    Plamadeala, P.
    Miron, Ingrith Crenguta
    MEDICAL-SURGICAL JOURNAL-REVISTA MEDICO-CHIRURGICALA, 2014, 118 (03): : 612 - 617
  • [6] SUCCESSFUL USE OF CISPLATIN TO TREAT METASTATIC SEMINOMA DURING CISPLATIN-INDUCED ACUTE-RENAL-FAILURE
    FOX, JG
    KERR, DJ
    SOUKOP, M
    FARMER, JG
    ALLISON, MEM
    CANCER, 1991, 68 (08) : 1720 - 1723
  • [7] Role of iron in cisplatin-induced acute renal failure in rats.
    Baliga, R
    Zhang, ZW
    Baliga, M
    Shah, SV
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1996, 7 (09): : A2874 - A2874
  • [8] Beneficial effect of pentoxifylline on cisplatin-induced acute renal failure in rabbits
    Kim, YK
    Choi, TR
    Kwon, CH
    Kim, JH
    Woo, JS
    Jung, JS
    RENAL FAILURE, 2003, 25 (06) : 909 - 922
  • [9] Motor and Behavioral Changes in Mice With Cisplatin-Induced Acute Renal Failure
    Ali, B. H.
    Ramkumar, A.
    Madanagopal, T. T.
    Waly, M. I.
    Tageldin, M.
    Al-Abri, S.
    Fahim, M.
    Yasin, J.
    Nemmar, A.
    PHYSIOLOGICAL RESEARCH, 2014, 63 (01) : 35 - 45
  • [10] EFFECT OF GLYCINE ON CISPLATIN-INDUCED ACUTE-RENAL-FAILURE IN THE RAT
    LI, Q
    YATES, MS
    BOWMER, CJ
    BRITISH JOURNAL OF PHARMACOLOGY, 1993, 110 : P166 - P166
12345