Experimental and Theoretical Investigation of the Phase Behavior of Naproxen in Supercritical CO2

被引：28
|
作者：
Tuerk, Michael [1 ]
Kraska, Thomas [2 ]
机构：
[1] Univ Karlsruhe TH, Inst Tech Thermodynam & Kaltetech, D-76131 Karlsruhe, Germany
[2] Univ Cologne, Inst Phys Chem, D-50939 Cologne, Germany
来源：
JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2009年 / 54卷 / 05期
关键词：
RAPID EXPANSION; SOLUBILITY; FLUIDS; DRUGS; MICRONIZATION; REARRANGEMENT; EQUILIBRIA; PARTICLES; PRESSURE; SOLIDS;
D O I：
10.1021/je800920d
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
New experimental solubility data of Naproxen in supercritical CO2 for (313 to 353) K and pressures ranging from (15 to 40) MPa are presented. This covers the range where processes with supercritical fluids such as Rapid Expansion from Supercritical Fluids are typically performed. In addition, the solid-liquid-gas equilibrium line for the CO2 + Naproxen system was determined from (0.1 to 30) MPa. The solubility data are correlated by three different methods: two methods for the density-solubility correlation and one method for the pressure-solubility correlation. Different literature data and predictions of the sublimation pressure of Naproxen, which are required for the solubility correlation, are compared.
引用
收藏
页码：1592 / 1597
页数：6
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