Synthesis of substituted 3-(3-chloro-1H-pyrazol-5-yl)quinoxalin-2(1H)ones

被引：3

作者：

Steger, Stefan ^{[1
]}

Matuszczak, Barbara ^{[1
]}

机构：

[1] Univ Innsbruck, CCB, Inst Pharm Pharmaceut Chem, A-6020 Innsbruck, Austria

来源：

TETRAHEDRON | 2014年 / 70卷 / 38期

关键词：

Monomethoxy substituted 3-(3-chloro-1-H-pyrazol-5-yl)quinoxalin-2(1H)ones; 3,6-Dichloropyridazine-4-carboxamides; Pyridazine to pyrazole ring transformation; DERIVATIVES;

D O I：

10.1016/j.tet.2014.07.072

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetic strategies to gain access to all four isomers of 3-(3-chloro-1H-pyrazol-5-yl)quinoxalin-2(1H) ones with monosubstituted benzo core (i.e., compounds 8a-d) are described. Preparation of these heterocyclic compounds succeeded starting from only two different substituted 2-nitroanilines (i.e., 3-methoxy- and 4-methoxy-2-nitroaniline) in three or five steps, respectively. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：6763 / 6768

页数：6

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