Synthesis of substituted 3-(3-chloro-1H-pyrazol-5-yl)quinoxalin-2(1H)ones

被引：3
|
作者：
Steger, Stefan [1 ]
Matuszczak, Barbara [1 ]
机构：
[1] Univ Innsbruck, CCB, Inst Pharm Pharmaceut Chem, A-6020 Innsbruck, Austria
来源：
TETRAHEDRON | 2014年 / 70卷 / 38期
关键词：
Monomethoxy substituted 3-(3-chloro-1-H-pyrazol-5-yl)quinoxalin-2(1H)ones; 3,6-Dichloropyridazine-4-carboxamides; Pyridazine to pyrazole ring transformation; DERIVATIVES;
D O I：
10.1016/j.tet.2014.07.072
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthetic strategies to gain access to all four isomers of 3-(3-chloro-1H-pyrazol-5-yl)quinoxalin-2(1H) ones with monosubstituted benzo core (i.e., compounds 8a-d) are described. Preparation of these heterocyclic compounds succeeded starting from only two different substituted 2-nitroanilines (i.e., 3-methoxy- and 4-methoxy-2-nitroaniline) in three or five steps, respectively. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6763 / 6768
页数：6
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