Effects of garlic components diallyl sulfide and diallyl disulfide on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in human promyelocytic leukemia cells

被引：21

作者：

Lin, JG ^{[1
]}

Chen, GW ^{[1
]}

Su, CC ^{[1
]}

Hung, CF ^{[1
]}

Yang, CC ^{[1
]}

Lee, JH ^{[1
]}

Chung, JG ^{[1
]}

机构：

[1] China Med Coll, Dept Med, Inst Chinese Med Sci, Taichung 400, Taiwan

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2002年 / 30卷 / 2-3期

关键词：

diallyl sulfide; diallyl disulfide; 2-aminofluorene; HL-60; NAT;

D O I：

10.1142/S0192415X02000338

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Two components of garlic, diallyl sulfide (DAS) and diallyl disulfide (DADS), inhibited arylamine N-acetyltransferase (NAT) activity and 2-aminofluorene-DNA adduct in human promyelocytic leukemia cells (HL-60). The NAT activity was measured by high performance liquid chromatography assaying for amounts of N-acetyl-2-aminofluorene (2-AAF) and remaining 2-aminofluorene (2-AF). Cellular cytosols and intact cell suspensions were assayed, The inhibition of NAT activity and 2-AF-DNA adduct formation in human leukemia cells by DAS and DADS were dose-dependent and were directly proportional. The data also indicated that DAS and DADS decrease the apparent values of K-m and V-max from human leukemia cells in both assays. This is the first report of garlic components affecting human leukemia cell NAT activity and 2-AF-DNA adduct formation.

引用

页码：315 / 325

页数：11

共 46 条

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