Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020

被引：488
|
作者：
Leung, Kathy [1 ,2 ]
Shum, Marcus H. H. [1 ,2 ,3 ,4 ]
Leung, Gabriel M. [1 ,2 ]
Lam, Tommy T. Y. [1 ,2 ,3 ,4 ]
Wu, Joseph T. [1 ,2 ]
机构：
[1] Univ Hong Kong, LKS Fac Med, WHO Collaborating Ctr Infect Dis Epidemiol & Cont, Sch Publ Hlth, Hong Kong, Peoples R China
[2] Lab Data Discovery Hlth D24H, Hong Kong Sci Pk, Hong Kong, Peoples R China
[3] Univ Hong Kong, Sch Publ Hlth, State Key Lab Emerging Infect Dis, Hong Kong, Peoples R China
[4] Shantou Univ, Joint Inst Virol Shantou Univ & Univ Hong Kong, Guangdong Hongkong Joint Lab Emerging Infect Dis, Shantou, Peoples R China
来源：
EUROSURVEILLANCE | 2021年 / 26卷 / 01期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.2807/1560-7917.ES.2020.26.1.2002106
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Delta 69/Delta 70, circulating mainly between early September and mid-November, was 10% (6-13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Delta 69/Delta 70, circulating since late September, was 75% (70-80%) more transmissible than the 501N lineage.
引用
收藏
页码：15 / 21
页数：7
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