Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020

被引：488
|
作者：
Leung, Kathy [1 ,2 ]
Shum, Marcus H. H. [1 ,2 ,3 ,4 ]
Leung, Gabriel M. [1 ,2 ]
Lam, Tommy T. Y. [1 ,2 ,3 ,4 ]
Wu, Joseph T. [1 ,2 ]
机构：
[1] Univ Hong Kong, LKS Fac Med, WHO Collaborating Ctr Infect Dis Epidemiol & Cont, Sch Publ Hlth, Hong Kong, Peoples R China
[2] Lab Data Discovery Hlth D24H, Hong Kong Sci Pk, Hong Kong, Peoples R China
[3] Univ Hong Kong, Sch Publ Hlth, State Key Lab Emerging Infect Dis, Hong Kong, Peoples R China
[4] Shantou Univ, Joint Inst Virol Shantou Univ & Univ Hong Kong, Guangdong Hongkong Joint Lab Emerging Infect Dis, Shantou, Peoples R China
来源：
EUROSURVEILLANCE | 2021年 / 26卷 / 01期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.2807/1560-7917.ES.2020.26.1.2002106
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Delta 69/Delta 70, circulating mainly between early September and mid-November, was 10% (6-13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Delta 69/Delta 70, circulating since late September, was 75% (70-80%) more transmissible than the 501N lineage.
引用
收藏
页码：15 / 21
页数：7
相关论文
共 50 条
  • [1] SARS-CoV-2 N501Y variants of concern and their potential transmission by mouse
    Hongyan Huang
    Yichao Zhu
    Zubiao Niu
    Lulin Zhou
    Qiang Sun
    Cell Death & Differentiation, 2021, 28 : 2840 - 2842
  • [2] The N501Y spike substitution enhances SARS-CoV-2 infection and transmission
    Liu, Yang
    Liu, Jianying
    Plante, Kenneth S.
    Plante, Jessica A.
    Xie, Xuping
    Zhang, Xianwen
    Ku, Zhiqiang
    An, Zhiqiang
    Scharton, Dionna
    Schindewolf, Craig
    Widen, Steven G.
    Menachery, Vineet D.
    Shi, Pei-Yong
    Weaver, Scott C.
    NATURE, 2022, 602 (7896) : 294 - +
  • [3] SARS-CoV-2 N501Y variants of concern and their potential transmission by mouse
    Huang, Hongyan
    Zhu, Yichao
    Niu, Zubiao
    Zhou, Lulin
    Sun, Qiang
    CELL DEATH AND DIFFERENTIATION, 2021, 28 (10): : 2840 - 2842
  • [4] The N501Y spike substitution enhances SARS-CoV-2 infection and transmission
    Yang Liu
    Jianying Liu
    Kenneth S. Plante
    Jessica A. Plante
    Xuping Xie
    Xianwen Zhang
    Zhiqiang Ku
    Zhiqiang An
    Dionna Scharton
    Craig Schindewolf
    Steven G. Widen
    Vineet D. Menachery
    Pei-Yong Shi
    Scott C. Weaver
    Nature, 2022, 602 : 294 - 299
  • [5] The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages
    Martin, Darren P.
    Weaver, Steven
    Tegally, Houriiyah
    San, James Emmanuel
    Shank, Stephen D.
    Wilkinson, Eduan
    Lucaci, Alexander G.
    Giandhari, Jennifer
    Naidoo, Sureshnee
    Pillay, Yeshnee
    Singh, Lavanya
    Lessells, Richard J.
    Gupta, Ravindra K.
    Wertheim, Joel O.
    Nekturenko, Anton
    Murrell, Ben
    Harkins, Gordon W.
    Lemey, Philippe
    MacLean, Oscar A.
    Robertson, David L.
    de Oliveira, Tulio
    Pond, Sergei L. Kosakovsky
    CELL, 2021, 184 (20) : 5189 - +
  • [6] Immunity evasion: consequence of the N501Y mutation of the SARS-CoV-2 spike glycoprotein
    Henrietta Onyinye Uzoeto
    Judith Nnedimkpa Ajima
    Amarachukwu Vivian Arazu
    Glory Omini Ibiang
    Samuel Cosmas
    Olanrewaju Ayodeji Durojaye
    Journal of Genetic Engineering and Biotechnology, 20
  • [7] Detection of SARS-CoV-2 N501Y mutation among SARS-CoV-2 variants of concern circulating in Northern Cyprus
    Tuncel, Gulten
    Ergoren, Mahmut Cerkez
    Baddal, Buket
    Tulay, Pinar
    Ozverel, Cenk Serhan
    Guler, Emrah
    Suer, Huseyin Kaya
    Sayan, Murat
    Sanlidag, Tamer
    FUTURE VIROLOGY, 2022, 17 (08) : 523 - 528
  • [8] Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage
    Colson, Philippe
    Levasseur, Anthony
    Delerce, Jeremy
    Pinault, Lucile
    Dudouet, Pierre
    Devaux, Christian
    Fournier, Pierre-Edouard
    La Scola, Bernard
    Lagier, Jean-Christophe
    Raoult, Didier
    CLINICAL MICROBIOLOGY AND INFECTION, 2021, 27 (09) : 1352.e1 - 1352.e5
  • [9] Immunity evasion: consequence of the N501Y mutation of the SARS-CoV-2 spike glycoprotein
    Uzoeto, Henrietta Onyinye
    Ajima, Judith Nnedimkpa
    Arazu, Amarachukwu Vivian
    Ibiang, Glory Omini
    Cosmas, Samuel
    Durojaye, Olanrewaju Ayodeji
    JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY, 2022, 20 (01)
  • [10] Efficacy of Serotherapy on an N501Y Variant of SARS-CoV-2 in a Patient With Chronic Lymphocytic Leukemia
    Vercueil, Colin
    Eberst, Lauriane
    Humbrecht, Catherine
    Fornecker, Luc-Matthieu
    HEMASPHERE, 2021, 5 (12): : E655
12345