Nerve growth factor, neural stem cells and Alzheimer's disease

被引：77
|
作者：
Heese, Klaus
Low, Jin Wei
Inoue, Noriko
机构：
[1] Nanyang Technol Univ, Sch Biol Sci, Dept Mol & Cell Biol, Singapore 637551, Singapore
[2] Osaka Univ Hosp, Med Ctr Translat Res, Suita, Osaka, Japan
来源：
NEUROSIGNALS | 2006年 / 15卷 / 01期
关键词：
Alzheimer's disease; apoptosis; nerve growth factor; neurodegeneration; neurotrophin; neural stem cells;
D O I：
10.1159/000094383
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The protein family of the neurotrophins (NTs) comprises structurally and functionally related molecules such as nerve growth factor (NGF) which influences the proliferation, differentiation, survival and death of neuronal cells. In addition to their established functions for cell survival, NTs also mediate higher brain activities such as learning and memory. Changes in NT expression levels have thus been implicated in neurological diseases such as Alzheimer's disease (AD), an age-related neurodegenerative disorder that is characterized by progressive loss of memory and deterioration of higher cognitive functions. The present review provides an overview of the functional role of NGF in neural stem cells and AD while pointing to a potential application of this peptide for the treatment of AD. Copyright (c) 2006 S. Karger AG, Basel
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页码：1 / 12
页数：12
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