Increased CSF levels of nerve growth factor in patients with Alzheimer's disease

被引：48

作者：

Hock, C

Heese, K

Müller-Spahn, F

Huber, P

Riesen, W

Nitsch, RM

Otten, U

机构：

[1] Univ Zurich, Dept Psychiat Res, CH-8029 Zurich, Switzerland

[2] Univ Basel, Dept Physiol, Basel, Switzerland

[3] Univ Basel, Dept Psychiat, Basel, Switzerland

[4] Univ Basel, Dept Clin Chem, Basel, Switzerland

[5] Natl Cardiovasc Ctr, BF Res Inst, Osaka, Japan

[6] State Hosp St Gallen, Inst Clin Chem & Hematol, St Gallen, Switzerland

来源：

NEUROLOGY | 2000年 / 54卷 / 10期

关键词：

neurotrophins; basal forebrain; dementia; ELISA;

D O I：

10.1212/WNL.54.10.2009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors quantitated CSF levels of nerve growth factor (NGF) in patients with AD, nondemented control subjects (CTR), and age-matched patients with major depression (DE). CSF levels of NGF were markedly higher in the AD group than in both the CTR and DE groups (p < 0.01 and p < 0.001). Increased CSF levels of NGF in AD patients may reflect reported accumulation of NGF in the AD brain and may constitute a candidate marker for clinical diagnosis and therapeutic monitoring.

引用

页码：2009 / 2011

页数：3

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