The Association between Autoantibodies and Peripheral Neuropathy in Lupus Nephritis

被引:9
|
作者
Su, Yu-Jih [1 ,2 ,3 ]
Huang, Chi-Ren [2 ,4 ]
Chang, Wen-Neng [2 ,4 ]
Tsai, Nai-Wen [2 ,4 ]
Kung, Chia-Te [2 ,5 ]
Lin, Wei-Che [2 ,6 ]
Huang, Chih-Cheng [2 ,4 ]
Su, Chih-Min [2 ,3 ,5 ]
Cheng, Ben-Chung [1 ,2 ,3 ]
Chang, Ya-Ting [2 ,3 ,4 ]
Lu, Cheng-Hsien [2 ,3 ,4 ]
机构
[1] Kaohsiung Chang Gung Mem Hosp, Dept Internal Med, Kaohsiung 833, Taiwan
[2] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan
[3] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 80424, Taiwan
[4] Kaohsiung Chang Gung Mem Hosp, Dept Neurol, Kaohsiung 833, Taiwan
[5] Kaohsiung Chang Gung Mem Hosp, Dept Emergency Med, Kaohsiung 833, Taiwan
[6] Kaohsiung Chang Gung Mem Hosp, Dept Radiol, Kaohsiung 833, Taiwan
关键词
GUILLAIN-BARRE-SYNDROME; PRESENTING FEATURE; ERYTHEMATOSUS; ANTIBODIES; CYCLOPHOSPHAMIDE; MANAGEMENT; DURATION; PATIENT; PROFILE;
D O I
10.1155/2014/524940
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background and Aim. The sensitivity and specificity of biomarkers used for predicting peripheral neuropathy in patients with systemic lupus erythematosus (SLE) and nephritis (SLE-LN) remain unsatisfactory. This study aimed to determine the autoantibodies levels in SLE-LN patients with peripheral neuropathy. Methods. Data of 559 SLE-LN patients were collected retrospectively, including titers of autoantibodies, electrodiagnostic studies, and clinical manifestations. Results. The neurologic manifestations of the SLE-LN patients were diverse and nonspecific. The prevalence rate of peripheral polyneuropathy was 2.68%, of which about 73.33% was mixed sensory-motor polyneuropathy. Numbness and functional gastrointestinal problems were the most prevalent symptoms and these were noted in every subtype of peripheral neuropathy. Among all the serology markers, anti-Ro was significantly associated with neuropathy related to SLE (P = 0.009). Conclusion. Peripheral neuropathy among LN patients is rare and may be easily overlooked. This study demonstrated that positive anti-Ro antibody may imply neuropathy in LN patients. Thus, anti-Ro can be considered a biomarker that should be added to the panel of conventional autoantibodies in LN patients.
引用
收藏
页数:5
相关论文
共 50 条
  • [31] Association between leukocyte infiltration and development of glomerulosclerosis in experimental lupus nephritis
    Kootstra, CJ
    Sutmuller, M
    Baelde, HJ
    de Heer, E
    Bruijn, JA
    JOURNAL OF PATHOLOGY, 1998, 184 (02): : 219 - 225
  • [32] Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients
    Zhou, X-J
    Yu, L.
    Zhu, L.
    Hou, P.
    Lv, J. -C.
    Yu, F.
    Zhang, H.
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2009, 27 (04) : 609 - 614
  • [33] Lack of association between antiphospholipid antibody and WHO classification in lupus nephritis
    Fofi, C
    Cuadrado, MJ
    Godfrey, T
    Abbs, I
    Khamashta, MA
    Hughes, GRV
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2001, 19 (01) : 75 - 77
  • [34] THE ASSOCIATION BETWEEN ECHOCARDIOGRAPHIC PARAMETERS AND MORTALITY IN CHINESE PATIENTS WITH LUPUS NEPHRITIS
    Chen, Junzhe
    Tang, Ying
    Xu, Anping
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2015, 30
  • [35] Peripheral Neuropathy in Systemic Lupus Erythematosus
    Oomatia, Amin
    Fang, Hong
    Petri, Michelle
    Birnbaum, Julius
    ARTHRITIS AND RHEUMATISM, 2012, 64 (10): : S264 - S264
  • [36] Peripheral neuropathy in systemic lupus erythematosus
    Malaver, DB
    Núñez, I
    OSTEOPOROSIS INTERNATIONAL, 2003, 14 : S96 - S97
  • [37] PERIPHERAL NEUROPATHY IN SYSTEMIC LUPUS ERYTHEMATOSUS
    Oomatia, Amin
    Petri, Michelle
    Fang, Hong
    Birnbaum, Julius
    RHEUMATOLOGY, 2012, 51 : 179 - 179
  • [38] Peripheral neuropathy in systemic lupus erythematosus
    Campello, I
    Almárcegui, C
    Velilla, J
    Hortells, JL
    Oliveros, A
    REVISTA DE NEUROLOGIA, 2001, 33 (01) : 27 - 30
  • [39] Peripheral neuropathy in systemic lupus erythematosus
    Huynh, C
    Ho, SL
    Fong, KY
    Cheung, RTF
    Mok, CC
    Lau, CS
    JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 1999, 16 (02) : 164 - 168
  • [40] Association Analysis of the MHC in Lupus Nephritis
    Xu, Ricong
    Li, Qibin
    Liu, Rongjun
    Shen, Juan
    Li, Ming
    Zhao, Minghui
    Wang, Meng
    Liao, Qijun
    Mao, Haiping
    Li, Zhijian
    Zhou, Na
    Yin, Peiran
    Li, Yue
    Tang, Xueqing
    Wu, Tian
    Zhong, Zhong
    Wang, Yan
    Ai, Zhen
    Wang, Ou
    Chen, Na
    Yang, Xiaoqin
    Fang, Junbin
    Fu, Ping
    Gu, Jieruo
    Ye, Kun
    Chen, Jian
    Dai, Lie
    Liu, Huafeng
    Liu, Zhangsuo
    Liao, Yunhua
    Wan, Jianxin
    Ding, Guohua
    Zhao, Jinghong
    Zhang, Hao
    Fu, Shuxia
    Sun, Liangdan
    Zhang, Xuejun
    Yang, Huanming
    Wang, Jian
    Wang, Jun
    Liu, Jianjun
    Li, Yingrui
    Yu, Xueqing
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2017, 28 (11): : 3383 - 3394