The Association between Autoantibodies and Peripheral Neuropathy in Lupus Nephritis

被引:9
|
作者
Su, Yu-Jih [1 ,2 ,3 ]
Huang, Chi-Ren [2 ,4 ]
Chang, Wen-Neng [2 ,4 ]
Tsai, Nai-Wen [2 ,4 ]
Kung, Chia-Te [2 ,5 ]
Lin, Wei-Che [2 ,6 ]
Huang, Chih-Cheng [2 ,4 ]
Su, Chih-Min [2 ,3 ,5 ]
Cheng, Ben-Chung [1 ,2 ,3 ]
Chang, Ya-Ting [2 ,3 ,4 ]
Lu, Cheng-Hsien [2 ,3 ,4 ]
机构
[1] Kaohsiung Chang Gung Mem Hosp, Dept Internal Med, Kaohsiung 833, Taiwan
[2] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan
[3] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 80424, Taiwan
[4] Kaohsiung Chang Gung Mem Hosp, Dept Neurol, Kaohsiung 833, Taiwan
[5] Kaohsiung Chang Gung Mem Hosp, Dept Emergency Med, Kaohsiung 833, Taiwan
[6] Kaohsiung Chang Gung Mem Hosp, Dept Radiol, Kaohsiung 833, Taiwan
关键词
GUILLAIN-BARRE-SYNDROME; PRESENTING FEATURE; ERYTHEMATOSUS; ANTIBODIES; CYCLOPHOSPHAMIDE; MANAGEMENT; DURATION; PATIENT; PROFILE;
D O I
10.1155/2014/524940
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background and Aim. The sensitivity and specificity of biomarkers used for predicting peripheral neuropathy in patients with systemic lupus erythematosus (SLE) and nephritis (SLE-LN) remain unsatisfactory. This study aimed to determine the autoantibodies levels in SLE-LN patients with peripheral neuropathy. Methods. Data of 559 SLE-LN patients were collected retrospectively, including titers of autoantibodies, electrodiagnostic studies, and clinical manifestations. Results. The neurologic manifestations of the SLE-LN patients were diverse and nonspecific. The prevalence rate of peripheral polyneuropathy was 2.68%, of which about 73.33% was mixed sensory-motor polyneuropathy. Numbness and functional gastrointestinal problems were the most prevalent symptoms and these were noted in every subtype of peripheral neuropathy. Among all the serology markers, anti-Ro was significantly associated with neuropathy related to SLE (P = 0.009). Conclusion. Peripheral neuropathy among LN patients is rare and may be easily overlooked. This study demonstrated that positive anti-Ro antibody may imply neuropathy in LN patients. Thus, anti-Ro can be considered a biomarker that should be added to the panel of conventional autoantibodies in LN patients.
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页数:5
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