Cancer chemopreventive activity of serratane-type triterpenoids from Picea jezoensis

被引：12
|
作者：
Tanaka, R
Minami, T
Ishikawa, Y
Tokuda, H
Matsunaga, S
机构：
[1] Osaka Univ Pharmaceut Sci, Dept Med Chem, Takatsuki, Osaka 5691094, Japan
[2] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan
来源：
CHEMISTRY & BIODIVERSITY | 2004年 / 1卷 / 06期
关键词：
D O I：
10.1002/cbdv.200490070
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To search for cancer chemopreventive agents from natural sources, 13alpha,14alpha-epoxy-21alpha-methoxyserratan-3one, 21alpha-methoxyserrat-13-en-3-one, and 21alpha-hydroxy-3beta-methoxyserrat-14-en-30-al isolated from the cuticle of Picea jezoensis (SIEB. et Zucc.) CARR. var jezoensis (Pinaceae) were investigated for inhibitory effects in a two-stage mouse skin carcinogenesis test on mouse skin with 7,12-dimethylbenz[a]anthracene (DMBA) as initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as promoter. 21alpha-hydroxy-3beta-methoxyserrat-14-en-30-al and 13a,14a-epoxy-2la-methoxyserratan-3-one were found to exhibit strong antitumor-promoting activities in the in vivo carcinogenesis test.
引用
收藏
页码：878 / 885
页数：8
相关论文
共 50 条
  • [31] Breast cancer chemopreventive activity of polysaccharides from starfish in vitro
    Nam, Kyung-Soo
    Kim, Cheorl-Ho
    Shon, Yun-Hee
    [J]. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2006, 16 (09) : 1405 - 1409
  • [32] Cancer chemopreventive activity of phenylpropanoids and phytoquinoids from Illicium plants
    Itoigawa, M
    Ito, C
    Tokuda, H
    Enjo, F
    Nishino, H
    Furukawa, H
    [J]. CANCER LETTERS, 2004, 214 (02) : 165 - 169
  • [33] New cinnamylphenols from Dalbergia species with cancer chemopreventive activity
    Ito, C
    Itoigawa, M
    Kanematsu, T
    Ruangrungsi, N
    Higashihara, H
    Tokuda, H
    Nishino, H
    Furukawa, H
    [J]. JOURNAL OF NATURAL PRODUCTS, 2003, 66 (12): : 1574 - 1577
  • [34] Oleanane-Type Triterpenoids from Aceriphyllum rossii and Their Cytotoxic Activity
    Le Thi Kim Van
    Tran Manh Hung
    Phuong Thien Thuong
    Tran Minh Ngoc
    Kim, Jin Cheol
    Jang, Han-Su
    Cai, Xing Fu
    Oh, Sei Ryang
    Min, Byung-Sun
    Woo, Mi Hee
    Choi, Jae Sue
    Lee, Hyeong Kyu
    Bea, KiHwan
    [J]. JOURNAL OF NATURAL PRODUCTS, 2009, 72 (08): : 1419 - 1423
  • [35] Iridal-type triterpenoids with ichthyotoxic activity from Belamcanda chinensis
    Ito, H
    Onoue, S
    Miyake, Y
    Yoshida, T
    [J]. JOURNAL OF NATURAL PRODUCTS, 1999, 62 (01): : 89 - 93
  • [36] Anti-initiating activity of 3β-methoxy-13α,14α-epoxyserratan-21β-ol (PJJ-34) from the stem bark of Picea jezoensis CARR. var. jezoensis
    Tanaka, Reiko
    Minami, Toshifumi
    Tokuda, Harukuni
    [J]. CHEMISTRY & BIODIVERSITY, 2006, 3 (07) : 818 - 824
  • [37] Lung Cancer Chemopreventive Activity of Patulin Isolated from Penicillium vulpinum
    Monteillier, Aymeric
    Allard, Pierre-Marie
    Gindro, Katia
    Wolfender, Jean-Luc
    Cuendet, Muriel
    [J]. MOLECULES, 2018, 23 (03):
  • [38] Evaluation of selected lichens from Iceland for cancer chemopreventive and cytotoxic activity
    Ingólfsdóttir, K
    Lee, SK
    Bhat, KPL
    Lee, K
    Chai, HB
    Kristinsson, H
    Song, LL
    Gills, J
    Gudmundsdóttir, JT
    Mata-Greenwood, E
    Jang, MS
    Pezzuto, JM
    [J]. PHARMACEUTICAL BIOLOGY, 2000, 38 (04) : 313 - 317
  • [39] Cancer chemopreventive activity of constituents from Sedum dasyphyllum L.
    Van Diermen, D.
    Pierreclos, M.
    Hostettmann, K.
    Cuendet, M.
    [J]. PLANTA MEDICA, 2010, 76 (12) : 1212 - 1213
  • [40] Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop
    Gerhauser, C
    Alt, A
    Heiss, E
    Gamal-Eldeen, A
    Klimo, K
    Knauft, J
    Neumann, I
    Scherf, HR
    Frank, N
    Bartsch, H
    Becker, H
    [J]. MOLECULAR CANCER THERAPEUTICS, 2002, 1 (11) : 959 - 969
12345