Pathogen recognition by innate immunity and its signaling

被引：182
|
作者：
Akira, Shizuo [1 ]
机构：
[1] Osaka Univ, Host Def Lab, WPI Immunol Frontier Res Ctr, Suita, Osaka 5650871, Japan
来源：
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 2009年 / 85卷 / 04期
关键词：
Toll-like receptor; innate immunity; pathogen; interferon; signaling; cytokine; NF-KAPPA-B; DOUBLE-STRANDED-RNA; DOMAIN-CONTAINING ADAPTER; IFN-REGULATORY FACTOR-3; TANK-BINDING KINASE-1; RIG-I; CUTTING EDGE; TRANSCRIPTION FACTORS; DIFFERENTIAL ROLES; ACTIVATION;
D O I：
10.2183/pjab.85.143
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Mammalian immune response can be divided into innate and acquired immunity. Furthermore, much evidence has demonstrated that activation of innate immunity is a prerequisite to induction of acquired immunity. This paradigm shift has changed our thinking on the pathogenesis and treatment of infections, immune diseases, allergy, and cancers.
引用
收藏
页码：143 / 156
页数：14
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