Endothelin-induced c-fos expression in the rat forebrain

被引：4
|
作者：
Kurokawa, K [1 ]
Yamada, H [1 ]
Ochi, J [1 ]
机构：
[1] SHIGA UNIV MED SCI, DEPT ANAT, OTSU, SHIGA 52021, JAPAN
来源：
ACTA HISTOCHEMICA ET CYTOCHEMICA | 1997年 / 30卷 / 01期
关键词：
rat; hypothalamus; endothelin; c-Fos; immunohistochemistry;
D O I：
10.1267/ahc.30.51
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The expression of c-fos was analyzed immunohistochemically after injection of endothelin isopeptide into cerebroventricle of the rat. The c-Fos immunoreactivity increased and reached the peak at 1 hr-1.5 hr after the administration of endothelin. Endothelin-1 and endothelin-2 specifically induced c-fos expression in the neurons of paraventricular, supraoptic and periventricular nuclei and zona incerta. Endothelin-3 induced c-Fos in the organum vasculosum laminae terminalis in addition to those regions. In these areas, the number of c-Fos-positive neurons increased with a dose (0 to 100 pg of ET) dependent manner. We presume that they are the targeting neurons of central nervous endothelins (ETs).
引用
收藏
页码：51 / 56
页数：6
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