Modulation of c-fos expression in the rat striatum by diazepam

被引：16
|
作者：
Niles, LP
Smith, LJ
Tenn, CC
机构：
[1] Department of Biomedical Sciences, HSC 4N77, McMaster University, Hamilton, Ont. L8N 3Z5
来源：
NEUROSCIENCE LETTERS | 1997年 / 236卷 / 01期
基金：
加拿大自然科学与工程研究理事会;
关键词：
benzodiazepine-GABA(A) receptor; GABAergic activity; dopamine; glutamate; amphetamine; fos protein; hippocampus;
D O I：
10.1016/S0304-3940(97)00755-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The benzodiazepine agonist, diazepam, inhibits cAMP production in the rat brain. Since cAMP influences c-fos activity, we examined the effects of diazepam on expression of this immediate early gene, as indicated by Western blot analysis. Intraperitoneal administration of diazepam increased Fos protein levels in the striatum, but not in the hippocampus. In contrast, pretreatment with diazepam blocked the potent inducing effect of amphetamine, in both brain regions. Similar induction and blockade effects were also observed for a 90 kDa Fos related antigen (Fra), in the striatum and hippocampus, The possible mechanisms underlying the modulatory effects of diazepam on c-fos expression in the brain are discussed. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码：5 / 8
页数：4
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