Mitochondria-targeted ratiometric fluorescent probes for micropolarity and microviscosity and their applications

被引：32
|
作者：
Cui, Jingjing [1 ]
Yao, Yuhua [1 ]
Chen, Cong [1 ]
Huang, Rui [1 ]
Zhang, Weibing [1 ]
Qian, Junhong [1 ]
机构：
[1] East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2019年 / 30卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Fluorescent probe; Mitochondria; Microviscosity; Micropolarity; CELL; VISCOSITY; POLARITY; ROTOR;
D O I：
10.1016/j.cclet.2018.12.031
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two fluorescent "off-on" probes YYH1 and YYH2 were used for the detection of mitochondrial polarity and viscosity. Both probes have two emission bands: The peak of shorter wavelength was sensitive to the polarity, while that in longer wavelength region was sensitive to the viscosity, which enables us to detect medium polarity and viscosity simultaneously. The lg(I-short/I-long) of YYH1 exhibited linear relationship to the solvent polarity, while that of YYH2 was closely related to the solvent viscosity. Furthermore, both probes showed potential in bioimaging mitochondrial polarity or viscosity in living cells. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1071 / 1074
页数：4
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