Direct downregulation of MYC in AML cells using promoter G-quadruplex interacting small molecules

被引:0
|
作者
Turnidge, Megan A. [1 ]
Wai, Daniel H. [2 ]
Patel, Apurvi [2 ]
Montoya, Justin J. [2 ]
Lee, David W. [2 ]
Hurley, Laurence H. [3 ]
Gokhale, Vijay [3 ]
Arceci, Robert J. [2 ]
Azorsa, David O. [2 ]
机构
[1] Univ Arizona COM Phoenix, Phoenix, AZ USA
[2] Phoenix Childrens Hosp, Phoenix, AZ USA
[3] Univ Arizona, Tucson, AZ USA
关键词
D O I
10.1158/1538-7445.PEDCA17-B04
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B04
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay
    Kaiser, Christine E.
    Gokhale, Vijay
    Yang, Danzhou
    Hurley, Laurence H.
    QUADRUPLEX NUCLEIC ACIDS, 2013, 330 : 1 - 21
  • [42] Exploring the Interaction of New Pyridoquinazoline Derivatives with G-Quadruplex in the c-MYC Promoter Region
    Princiotto, Salvatore
    Karelou, Maria
    Ioannidi, Rachel
    Beretta, Giovanni Luca
    Zaffaroni, Nadia
    Artali, Roberto
    Kostakis, Ioannis K.
    Mazzini, Stefania
    Dallavalle, Sabrina
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (18)
  • [43] Downregulation of gene expression in hypoxic cancer cells by an activatable G-quadruplex stabiliser
    Uyar, Busra
    Ozsamur, Nezahat Gokce
    Celik, Fatma Secer
    Ozbayram, Ilkyaz
    Erbas-Cakmak, Sundus
    CHEMICAL COMMUNICATIONS, 2023, 59 (16) : 2247 - 2250
  • [44] Targeted downregulation of MYC through G-quadruplex stabilization: a novel therapeutic approach for breast cancer and lymphoma
    Chang, Katarina T.
    Hao, Taisen
    DeSouza, Harriet E. J.
    Brooks, Tracy Ann
    FASEB JOURNAL, 2018, 32 (01):
  • [45] Erratum: Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter
    Anh Tuân Phan
    Vitaly Kuryavyi
    Hai Yan Gaw
    Dinshaw J Patel
    Nature Chemical Biology, 2005, 1 : 234 - 234
  • [46] The binding of a c-MYC promoter G-quadruplex to neurotransmitters: An analysis of G-quadruplex stabilization using DNA melting, fluorescence spectroscopy, surface-enhanced Raman scattering and molecular docking
    Andregic, Nicole
    Weaver, Caitlin
    Basu, Swarna
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023, 1867 (12):
  • [47] Activity of G-quadruplex stabilizing small molecule that downregulates MYC and synergizes with Navitoclax in acute myeloid leukemia cells
    Montoya, Justin J.
    Turnidge, Megan A.
    Wai, Daniel H.
    Lee, David W.
    Patel, Apruvi
    Gokhale, Vijay
    Hurley, Laurence J.
    Azorsa, David O.
    CANCER RESEARCH, 2019, 79 (13)
  • [48] Frontiers in G-Quadruplex therapeutics in cancer: Selection of small molecules, peptides and aptamers
    Banerjee, Nilanjan
    Panda, Suman
    Chatterjee, Subhrangsu
    CHEMICAL BIOLOGY & DRUG DESIGN, 2022, 99 (01) : 1 - 31
  • [49] An exonuclease I hydrolysis assay for evaluating G-quadruplex stabilization by small molecules
    Yao, Yuan
    Wang, Quan
    Hao, Yu-hua
    Tan, Zheng
    NUCLEIC ACIDS RESEARCH, 2007, 35 (09)
  • [50] Identification of small molecules capable of regulating conformational changes of telomeric G-quadruplex
    Chen, Shuo-Bin
    Liu, Guo-Cai
    Gu, Lian-Quan
    Huang, Zhi-Shu
    Tan, Jia-Heng
    JOURNAL OF MOLECULAR STRUCTURE, 2018, 1154 : 1 - 7