Direct downregulation of MYC in AML cells using promoter G-quadruplex interacting small molecules

被引:0
|
作者
Turnidge, Megan A. [1 ]
Wai, Daniel H. [2 ]
Patel, Apurvi [2 ]
Montoya, Justin J. [2 ]
Lee, David W. [2 ]
Hurley, Laurence H. [3 ]
Gokhale, Vijay [3 ]
Arceci, Robert J. [2 ]
Azorsa, David O. [2 ]
机构
[1] Univ Arizona COM Phoenix, Phoenix, AZ USA
[2] Phoenix Childrens Hosp, Phoenix, AZ USA
[3] Univ Arizona, Tucson, AZ USA
关键词
D O I
10.1158/1538-7445.PEDCA17-B04
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B04
引用
收藏
页数:2
相关论文
共 50 条
  • [21] In silico identification of novel ligands for G-quadruplex in the c-MYC promoter
    Hyun-Jin Kang
    Hyun-Ju Park
    Journal of Computer-Aided Molecular Design, 2015, 29 : 339 - 348
  • [22] Solution structure of the biologically relevant g-quadruplex element in the human c-MYC promoter. implications for g-quadruplex stabilization
    Ambrus, A
    Chen, D
    Dai, JX
    Jones, RA
    Yang, DZ
    BIOCHEMISTRY, 2005, 44 (06) : 2048 - 2058
  • [23] Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation
    Keller, Josephine Geertsen
    Hymoller, Kirstine Mejlstrup
    Thorsager, Maria Eriksen
    Hansen, Noriko Y.
    Erlandsen, Jens Uldum
    Tesauro, Cinzia
    Simonsen, Anne Katrine W.
    Andersen, Anne Bech
    Vands-Petersen, Kamilla
    Holm, Lise Lolle
    Stougaard, Magnus
    Andresen, Brage Storstein
    Kristensen, Peter
    Frohlich, Rikke
    Knudsen, Birgitta R.
    NUCLEIC ACIDS RESEARCH, 2022, 50 (11) : 6332 - 6342
  • [24] In silico identification of novel ligands for G-quadruplex in the c-MYC promoter
    Kang, Hyun-Jin
    Park, Hyun-Ju
    JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2015, 29 (04) : 339 - 348
  • [25] G-QUADRUPLEX MOTIFS IN C MYC PROMOTER REGION AND THE ROLE OF VARIOUS SMALL MOLECULE LIGANDS/PROTEINS IN STABILIZING THIS PROMOTER REGION
    Tyagi, Shikhar
    Saxena, Sarika
    Kundu, Nikita
    Sharma, Taniya
    Kaur, Sarvpreet
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2021, 12 (01): : 22 - 43
  • [26] Selective suppression of Myc transcription with a G-quadruplex stabilizing small molecule
    Simmons, John K.
    Saunders, Lindsey B.
    Felsenstein, Kenneth
    Gareiss, Peter
    Zhang, Shuling
    Mock, Beverly
    Schneekloth, John S., Jr.
    MOLECULAR CANCER RESEARCH, 2015, 13
  • [27] Selective inhibition of MYC expression by a small molecule G-quadruplex stabilizer
    Leon, Elena C.
    Simmons, John K.
    Calabrese, David
    DuBois, Wendy
    Felsenstein, Kenneth
    Saunders, Lindsey B.
    Zhang, Shuling
    Michalowski, Aleksandra
    Gonzalez, Frank
    Mock, Beverly A.
    Schneekloth, John S.
    CANCER RESEARCH, 2016, 76
  • [28] Up- and downregulation of mature miR-1587 function by modulating its G-quadruplex structure and using small molecules
    Li, Fangyuan
    Tan, Wei
    Chen, Han
    Zhou, Jiang
    Xu, Ming
    Yuan, Gu
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 121 : 127 - 134
  • [29] Anticancer Activity and Cellular Repression of c-MYC by the G-Quadruplex-Stabilizing 11-Piperazinylquindoline Is Not Dependent on Direct Targeting of the G-Quadruplex in the c-MYC Promoter
    Boddupally, Peda V. L.
    Hahn, Seongmin
    Beman, Cristina
    De, Biswanath
    Brooks, Tracy A.
    Gokhale, Vijay
    Hurley, Laurence H.
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (13) : 6076 - 6086
  • [30] Effects of Salt on the Stability of a G-Quadruplex from the Human c-MYC Promoter
    Kim, Byul
    BIOPHYSICAL JOURNAL, 2016, 110 (03) : 405A - 405A