Comparative study of hydroxyapatite prepared from eggshells and synthetic precursors by microwave irradiation method for medical applications

Recently research on biogenic derived hydroxyapatite (HAp) is being focused. In the present study it is proposed to make a comparative analysis of microwave synthesised HAp derived from eggshell based calcium precursor with two commercial calcium soruces calcium nitrate tetrahydrate and calcium carbonate using EDTA as the organic modifier. The as-synthesized samples was characterized by XRD, FT-IR, SEM and EDAX. Comparative studies were carried out with eggshell derived HAp and synthetic precursors. Eggshell derived HAp exhibited lesser decomposition into beta-TCP and EDAX confirmed the presence of magnesium element with plays a key role in bone metabolism. Eggshell derived hydroxyapatite also revealed somewhat better changes in the cytocompatibility, antimicrobial activity and drug release. (C) 2019 Elsevier Ltd. All rights reserved.