Gold Nanoparticles for Nucleic Acid Delivery

被引：368
|
作者：
Ding, Ya [1 ,2 ]
Jiang, Ziwen [1 ]
Saha, Krishnendu [1 ]
Kim, Chang Soo [1 ]
Kim, Sung Tae [1 ]
Landis, Ryan F. [1 ]
Rotello, Vincent M. [1 ]
机构：
[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
[2] China Pharmaceut Univ, Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Dept Pharmaceut Anal, Nanjing, Jiangsu, Peoples R China
来源：
MOLECULAR THERAPY | 2014年 / 22卷 / 06期
基金：
美国国家卫生研究院;
关键词：
TRANSDERMAL DRUG-DELIVERY; GENE DELIVERY; SIRNA DELIVERY; MULTIFUNCTIONAL NANOPARTICLES; MAMMALIAN-CELLS; CELLULAR UPTAKE; PLASMID DNA; INORGANIC NANOPARTICLES; SURFACE FUNCTIONALITY; CARBON NANOTUBES;
D O I：
10.1038/mt.2014.30
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene delivery and RNA-interference technologies. We also discuss challenges in nucleic acid delivery, including endosomal entrapment/escape and active delivery/presentation of nucleic acids in the cell.
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页码：1075 / 1083
页数：9
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