Silica nanoparticles as a delivery system for nucleic acid-based reagents

被引：64

作者：

Hom, Christopher ^{[1
]}

Lu, Jie ^{[1
]}

Tamanoi, Fuyuhiko ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Calif NanoSyst Inst, Dept Microbiol Mol Genet & Immunol, JCCC, Los Angeles, CA 90095 USA

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2009年 / 19卷 / 35期

关键词：

VIVO GENTAMICIN RELEASE; MESENCHYMAL STEM-CELLS; MESOPOROUS SILICA; GENE DELIVERY; DNA DELIVERY; IN-VIVO; GROWTH-FACTOR; ANTISENSE OLIGONUCLEOTIDES; DRUG-DELIVERY; TRANSFECTION EFFICIENCY;

D O I：

10.1039/b904197d

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The transport of nucleic acid-based reagents is predicated upon developing structurally stable delivery systems that can preferentially bind and protect DNA and RNA, and release their cargo upon reaching their designated sites. Recent advancements in tailoring the size, shape, and external surface functionalization of silica materials have led to increased biocompatibility and efficiency of delivery. In this Feature Article, we highlight recent research progress in the use of silica nanoparticles as a delivery vehicle for nucleic acid-based reagents.

引用

页码：6308 / 6316

页数：9

共 50 条

[1] Modification of Lipid-Based Nanoparticles: An Efficient Delivery System for Nucleic Acid-Based Immunotherapy
Zhang, Chi
Ma, Yifan
Zhang, Jingjing
Kuo, Jimmy Chun-Tien
Zhang, Zhongkun
Xie, Haotian
Zhu, Jing
Li, Tongzheng
[J]. MOLECULES, 2022, 27 (06):
[2] Functionalization of silica nanoparticles for nucleic acid delivery
Rimpei Kamegawa
Mitsuru Naito
Kanjiro Miyata
[J]. Nano Research, 2018, 11 : 5219 - 5239
[3] Engineered Silica Nanoparticles for Nucleic Acid Delivery
Zhang, Yue
Yu, Yingjie
Yang, Yannan
Wang, Yue
Yu, Chengzhong
[J]. SMALL METHODS, 2024, 8 (03)
[4] Functionalization of silica nanoparticles for nucleic acid delivery
Kamegawa, Rimpei
Naito, Mitsuru
Miyata, Kanjiro
[J]. NANO RESEARCH, 2018, 11 (10) : 5219 - 5239
[5] Oral delivery of nucleic acid-based therapeutics
Hardee, Gregory E.
[J]. THERAPEUTIC DELIVERY, 2012, 3 (02) : 143 - 145
[6] Responsive Nucleic Acid-Based Organosilica Nanoparticles
Picchetti, Pierre
Volpi, Stefano
Rossetti, Marianna
Dore, Michael D.
Trinh, Tuan
Biedermann, Frank
Neri, Martina
Bertucci, Alessandro
Porchetta, Alessandro
Corradini, Roberto
Sleiman, Hanadi
De Cola, Luisa
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 145 (42) : 22896 - 22902
[7] Propaedeutic study for the delivery of nucleic acid-based molecules from PLGA microparticles and stearic acid nanoparticles
Grassi, G.
Coceani, N.
Farra, R.
Dapas, B.
Racchi, G.
Fiotti, N.
Pascotto, A.
Rehimers, B.
Guarnieri, G.
Grassi, M.
[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2006, 1 (04): : 523 - 533
[8] Polydopamine functionalized dendritic fibrous silica nanoparticles as a generic platform for nucleic acid-based biosensing
Xiaoting Xue
Helena Persson
Lei Ye
[J]. Microchimica Acta, 2024, 191
[9] Polydopamine functionalized dendritic fibrous silica nanoparticles as a generic platform for nucleic acid-based biosensing
Xue, Xiaoting
Persson, Helena
Ye, Lei
[J]. MICROCHIMICA ACTA, 2024, 191 (04)
[10] The Potential of Nucleic Acid-Based Nanoparticles for Biomedical Application
Biocca, Silvia
Desideri, Alessandro
[J]. NANO LIFE, 2015, 5 (04)

← 1 2 3 4 5 →