6-Substituted pyrido[3,2-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic agents

被引:0
|
作者
Gangjee, Aleem [1 ]
Shah, Khushbu [1 ]
Cody, Vivian [2 ]
机构
[1] Duquesne Univ, Grad Sch Pharm Sci, Pittsburgh, PA 15219 USA
[2] Hauptman Woodward Inst, Buffalo, NY USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
414
引用
收藏
页数:1
相关论文
共 50 条
  • [31] Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2-d] pyrimidine analogues as antifolate antitumor agents
    Tian, Chao
    Wang, Meng
    Han, Zifei
    Fang, Fang
    Zhang, Zhili
    Wang, Xiaowei
    Liu, Junyi
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 138 : 630 - 643
  • [32] Synthesis and Anti-tumor Activity Evaluation of a Series of 2-or 4-Substituted Pyrido [3,2-d] pyrimidines as Nonclassical Antifolates
    Fang Fang
    Xue Liangmin
    Cong Jing
    Tian Chao
    Wang Xiaowei
    Liu Junyi
    Zhang Zhili
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2019, 40 (10): : 2111 - 2120
  • [33] SYNTHESIS OF PYRIDO(2,3-D)- AND -(3,2-D)-SYM-TRIAZOLO(3,4-F)PYRIMIDINES AND OF 4-(1 -PYRAZOLYL)PYRIDO(2,3-D)- AND -(3,2-D)PYRIMIDINES
    GODEFROY, L
    QUEGUINE.G
    PASTOUR, P
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1973, 10 (06) : 1077 - 1078
  • [34] Design and synthesis of substituted pyrido[3,2-d]-1,2,3-triazines as potential Pim-1 inhibitors
    Fan, Yin-Bo
    Li, Kun
    Huang, Min
    Cao, Yu
    Li, Ying
    Jin, Shu-Yu
    Liu, Wen-Bing
    Wen, Jia-Chen
    Liu, Dan
    Zhao, Lin-Xiang
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (04) : 1224 - 1228
  • [35] Design, Synthesis of 6-Substituted-pyrido[3,2-d]pyridazine Derivatives with Anticonvulsant Activity
    Dong, Zheng-Qi
    Liu, Xiao-Mei
    Wei, Cheng-Xi
    Quan, Zhe-Shan
    MEDICINAL CHEMISTRY, 2015, 11 (06) : 595 - 601
  • [36] 6244: Design, synthesis, and structure-activity relationships of substituted pyrido[ 3,2d] pyrimidines as microtubule targeting agents and anti- cancer agents
    Shah, Yesha Vijaykumar
    Bai, Ruoli
    Hamel, Ernest
    Gangjee, Aleem
    CANCER RESEARCH, 2023, 83 (07)
  • [37] SYNTHESIS OF PYRIDO [2,3-D] AND [3,2-D] S-TRIAZOLO [3,4-F] PYRIMIDINES AND OF PYRIDO [2,3-D] AND [3,2-D] TETRAZOLO [5,1-F) PYRIMIDINES
    GODEFROY, L
    DECORMEI.A
    QUEGUINE.G
    PASTOUR, P
    COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES SERIE C, 1974, 278 (24): : 1421 - 1424
  • [38] Synthesis of thiazolidinones and azetidinones from hydrazino thieno [3,2-d]pyrimidines as potential antimicrobial agents
    Shah, M
    Parikh, K
    Parekh, H
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1998, 37 (01): : 73 - 77
  • [39] STUDIES ON CONDENSED PYRIMIDINE SYSTEMS .14. SOME PYRIDO [3,2-D] PYRIMIDINES
    ROBINS, RK
    HITCHINGS, GH
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1956, 78 (05) : 973 - 976
  • [40] An efficient synthesis of 4,6-substituted pyrrolo[3,2-d]pyrimidines by silver-catalyzed cyclization of acetylene amine
    Xie, Rui
    Hu, Ying
    Wan, Huixin
    Hu, Yanwei
    Chen, Shaohua
    Zhang, Shilei
    Zhang, Yinan
    TETRAHEDRON LETTERS, 2016, 57 (22) : 2418 - 2421