Synthesis of thiazolidinones and azetidinones from hydrazino thieno [3,2-d]pyrimidines as potential antimicrobial agents

4-Hydrazino-6-phenylthieno [3,2-d] pyrimidine 5 on treatment with aromatic aldehydes yield 4-substituted-benzalhydrazino-6-phenylthieno [3,2-d] pyrimidine 6a-k, which on cyclisation with thioglycolic and thiolactic acid afford corresponding 2-aryl-3-N-(6'-phenylthieno [3,2-d] pyrimid-4-yl-amino)-5-H/methyl-4-thiazolidinones 7a-k, 7'a-k. The same compounds 6a-k on reaction with chloroacetyl chloride and Et3N in dioxane furnish respective 4-aryl-3-chloro-1-N-(6'-phenylthieno [3,2-d] pyrimid-4-yl-amino)-2-azetidinones 8a-k. The structure of the compounds 6a-k, 7a-k, 7'a-k and 8a-k have been confirmed from elemental analyses, IR, H-1 NMR and mass spectral data. All the products have been evaluated for their in vitro growth inhibitory activity against several microbes like B. mega., B. subtilis, E. coli, A. aerogens and A. awamori.