Preclinical pharmacokinetics, pharmacodynamics and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates (vol 148, pg 1116, 2006)

被引:0
|
作者
Kelley, S. K.
Gelzleichter, T.
Xie, D.
Lee, W. P.
Darbonne, W. C.
Qureshi, F.
Kissler, K.
Oflazoglu, E.
Grewal, I. S.
机构
关键词
D O I
10.1038/sj.bjp.0707129
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:248 / 248
页数:1
相关论文
共 40 条
  • [31] A randomized, phase 1b study of the pharmacokinetics, pharmacodynamics, safety, and tolerability of bleselumab, a fully human, anti-CD40 monoclonal antibody, in kidney transplantation
    Vincenti, Flavio
    Klintmalm, Goran
    Yang, Harold
    Peddi, V. Ram
    Blahunka, Paul
    Conkle, Angela
    Santos, Vicki
    Holman, John
    AMERICAN JOURNAL OF TRANSPLANTATION, 2020, 20 (01) : 172 - 180
  • [32] Immunological aspects of non-human primates renal transplant recipients treated with a novel human anti-CD40 MAB, 4D11 and tacrolimus.
    Uno, Motobiro
    Yamashita, Kenichiro
    Suzuki, Tomomi
    Aoyagi, Takeshi
    Goto, Ryoichi
    Oura, Tetu
    Watanabe, Masaaki
    Miura, Toru
    Takahashi, Nobuaki
    Okimura, Kazumitsu
    Itoh, Tomoo
    Shimizu, Akira
    Taniguchi, Masahiko
    Shimamura, Tsuyoshi
    Furukawa, Hiroyuki
    Todo, Satoru
    AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 : 228 - 228
  • [33] Pharmacokinetics (PK) and Pharmacodynamics (PD) Studies of ASKP1240, a Novel Fully Human Anti-CD40 Monoclonal Antibody in Normal and Transplanted Cynomolgus Monkeys.
    Ma, A.
    Dun, H.
    Song, L.
    Hu, Y.
    Zhang, G.
    Zeng, L.
    Bai, J.
    Kinugasa, F.
    Miyao, Y.
    Kasai, N.
    Daloze, P.
    Chen, H.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2011, 11 : 348 - 348
  • [34] Human anti-CD40 antibody and poly IC:LC adjuvant combination induces potent T cell responses in the lung of nonhuman primates (vol 195, pg 1015, 2015)
    Thompson, E. A.
    Liang, F.
    Lindgren, G.
    Sandgren, K. J.
    Quinn, K. M.
    Darrah, P. A.
    Koup, R. A.
    Seder, R. A.
    Kedl, R. M.
    Lore, K.
    JOURNAL OF IMMUNOLOGY, 2015, 195 (07): : 3497 - 3498
  • [35] A Novel, Blocking Anti-CD40 Monoclonal Antibody Prolongs Non-Human Primate Renal Allograft Survival in the Absence of B-Cell Depletion Or Thromboembolic Events
    Rush, J.
    Wieczorek, G.
    Audet, M.
    Schneider, M.
    Espie, P.
    Roth, L.
    Heusser, C.
    Bruns, C.
    Patel, D.
    Cordoba, F.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2015, 15
  • [36] A NOVEL, BLOCKING ANTI-CD40 MONOCLONAL ANTIBODY PROLONGS NON-HUMAN PRIMATE RENAL ALLOGRAFT SURVIVAL IN THE ABSENCE OF B-CELL DEPLETION OR THROMBOEMBOLIC EVENTS
    Cordoba, Francisco
    Wieczorek, Grazyna
    Audet, Maxime
    Schneider, Martin A.
    Espie, Pascal
    Roth, Lukas
    Heusser, Christoph
    Bruns, Christian
    Patel, Dhavalkumar
    Haraldsson, Boerje
    Rush, James S.
    TRANSPLANT INTERNATIONAL, 2015, 28 : 123 - 123
  • [37] A novel, blocking anti-CD40 monoclonal antibody prolongs non-human primate renal allograft survival in the absence of B-cell depletion or thromboembolic events
    Cordoba, F.
    Wieczorek, G.
    Audet, M.
    Schneider, M.
    Espie, P.
    Roth, L.
    Heusser, C.
    Bruns, C.
    Patel, D.
    Rush, J.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 764 - 764
  • [38] Expression of Human Thrombomodulin on GTKO. CD46 Donor Pigs and Costimulation Blockade by Anti CD40 Antibody is Critical for Extending Cardiac Xenograft Survival in Non-human Primates
    Singh, Avneesh
    DiChiacchio, Laura
    Chan, Joshua L.
    Lewis, Billeta G. T.
    Thomas, Marvin L.
    Corcoran, Philip C.
    Ayares, David
    Horvath, Keith A.
    Mohiuddin, Muhammad M.
    TRANSPLANTATION, 2018, 102 : S741 - S741
  • [39] Efficacy of an antagonistic Anti-CD40 monoclonal antibody, HCD122 (CHIR-12.12), in preclinical models of human Non-Hodgkin's lymphoma and Hodgkin's disease.
    Long, Li
    Patawaran, Montesa
    Tong, Xia
    Kantak, Seema
    Aukerman, Sharon L.
    Pryer, Nancy
    Luqman, Mohammad
    BLOOD, 2006, 108 (11) : 72A - 72A
  • [40] An Fc-Engineered Humanized Anti-CD40 Monoclonal Antibody, XmAb5485, Exhibits Potent Activity in Vitro and in Vivo against Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia and Multiple Myeloma
    Zhukovsky, Eugene A.
    Horton, Holly
    Peipp, Matthias
    Pong, Erik
    Bernett, Matthew
    Karki, Sher
    Richards, John
    Chu, Seung
    Repp, Roland
    Desjarlais, John
    BLOOD, 2008, 112 (11) : 325 - 326