Preclinical pharmacokinetics, pharmacodynamics and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates (vol 148, pg 1116, 2006)

被引：0
|
作者：
Kelley, S. K.
Gelzleichter, T.
Xie, D.
Lee, W. P.
Darbonne, W. C.
Qureshi, F.
Kissler, K.
Oflazoglu, E.
Grewal, I. S.
机构：
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2007年 / 150卷 / 02期
关键词：
D O I：
10.1038/sj.bjp.0707129
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：248 / 248
页数：1
相关论文
共 40 条
  • [21] First-in-human clinical trial to assess pharmacokinetics, pharmacodynamics, safety, and tolerability of iscalimab, an anti-CD40 monoclonal antibody
    Espie, Pascal
    He, YanLing
    Koo, Phillip
    Sickert, Denise
    Dupuy, Cyrielle
    Chokote, Edwige
    Schuler, Roland
    Mergentaler, Heidi
    Ristov, Jacinda
    Milojevic, Julie
    Verles, Aurelie
    Groenewegen, Andrea
    Auger, Anita
    Avrameas, Alexandre
    Rotte, Michael
    Colin, Laurence
    Tomek, Charles S.
    Hernandez-Illas, Martha
    Rush, James S.
    Gergely, Peter
    AMERICAN JOURNAL OF TRANSPLANTATION, 2020, 20 (02) : 463 - 473
  • [22] Pharmacokinetics and Pharmacodynamics of ASKP1240, a Fully Human Anti-CD40 Antibody, in Normal and Renal Transplanted Cynomolgus Monkeys
    Ma, Anlun
    Dun, Hao
    Song, Lijun
    Hu, Yanxin
    Zeng, Lin
    Bai, Jieying
    Zhang, Guangzhou
    Kinugasa, Fumitaka
    Miyao, Yasuhiro
    Sakuma, Shozo
    Okimura, Kazumichi
    Kasai, Noriyuki
    Daloze, Pierre
    Chen, Huifang
    TRANSPLANTATION, 2014, 97 (04) : 397 - 404
  • [23] Preclinical Immunopharmacologic Assessment of KPL-404, a Novel, Humanized, Non-Depleting Antagonistic Anti-CD40 Monoclonal Antibody
    Muralidharan, Sujatha
    Njenga, Moses
    Garron, Tracy
    Bondensgaard, Kent
    Paolini, John F.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2022, 381 (01): : 12 - 21
  • [24] B Cell Depletion Is Not Required for Prolongation of Renal Allograft Survival in Non-Human Primates Using a Novel Anti-CD40 Blocking Antibody.
    Rush, J.
    Cordoba, F.
    Wieczorek, G.
    Audet, M.
    Schneider, M.
    Patel, D.
    Heusser, C.
    Bruns, C.
    Ulrich, P.
    Slade, A.
    Klupp, J.
    TRANSPLANTATION, 2014, 98 : 379 - 380
  • [25] SEA-CD40 is a non-fucosylated anti-CD40 antibody with potent pharmacodynamic activity in preclinical models and patients with advanced solid tumors
    Neff-LaFord, Haley
    Grilley-Olson, Juneko E.
    Smith, David C.
    Curti, Brendan
    Goel, Sanjay
    Kuzel, Timothy M.
    Markovic, Svetomir N.
    Rixe, Olivier
    Bajor, David L.
    Gajewski, Thomas F.
    Gutierrez, Martin
    Heath, Elisabeth I.
    Thompson, John
    Ansari, Sahar
    Gardai, Shyra
    Jacquemont, Celine
    Schmitt, Michael
    Coveler, Andrew L.
    CANCER RESEARCH, 2020, 80 (16)
  • [26] Comparative efficacy of anti-CD40 antibody mediated-costimulation blockade and anti-CD20 antibody/tacrolimus treatment on the survival of full thickness xenocorneal transplantation in non-human primates
    Kim, Mee Kum
    Yoon, Chang Ho
    Kim, Jaeyoung
    Lee, Hyun Ju
    Kwon, Hyunsang
    Kang, Hee Jung
    Park, Chung-Gyu
    Hwang, Eung-Soo
    Wee, Won Ryang
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 58 (08)
  • [27] Anti-CD40 antibody mediated-costimulation blockade promotes long-term survival of full thickness corneal xenotransplantation in non-human primates
    Yoon, Chang Ho
    Kim, Jaeyoung
    Choi, Se Hyun
    Lee, Hyun Ju
    Kang, Hee Jung
    Kim, Jong Min
    Park, Chung-Gyu
    Wee, Won Ryang
    Kim, Mee Kum
    XENOTRANSPLANTATION, 2017, 24 (05)
  • [28] Preclinical pharmacokinetics of a novel anti-c-Met antibody-drug conjugate, SHR-A1403, in rodents and non-human primates
    Yang, Changyong
    Zhao, Xiaoping
    Sun, Xing
    Li, Jinlong
    Wang, Weiqiang
    Zhang, Lianshan
    Gou, Shaohua
    XENOBIOTICA, 2019, 49 (09) : 1097 - 1105
  • [29] Long-Term Graft Acceptance by a Novel Human Anti-CD40 Monoclonal Antibody, 4D11, after Liver Transplantation in Non-Human Primates.
    Oura, Tetsu
    Yamashita, Kenichiro
    Suzuki, Tomomi
    Miura, Toru
    Haga, Hironori
    Shimizu, Akira
    Taniguchi, Masahiko
    Shimamura, Tsuyoshi
    Furukawa, Hiroyuki
    Todo, Satoru
    AMERICAN JOURNAL OF TRANSPLANTATION, 2009, 9 : 319 - 319
  • [30] Anti-CD40 antibody-mediated costimulation blockade promotes long-term survival of deep-lamellar porcine corneal grafts in non-human primates
    Kim, Jaeyoung
    Kim, Dong Hyun
    Choi, Hyuk Jin
    Lee, Hyun Ju
    Kang, Hee Jung
    Park, Chung-Gyu
    Hwang, Eung-Soo
    Kim, Mee Kum
    Wee, Won Ryang
    XENOTRANSPLANTATION, 2017, 24 (03)
1234