FABRICATION PROCESS OF INTEGRATED MULTI-ANALYTE BIOCHIP SYSTEM FOR IMPLANTABLE APPLICATION

被引:6
|
作者
Tsai, Y. -C. [1 ]
Chiu, N. -F. [2 ]
Liu, P. -C. [2 ]
Ou, Y-C [3 ]
Liao, H. -H. [1 ]
Yang, Y-J. [1 ]
Yang, L. -J. [3 ]
Lei, U. [4 ]
Chao, F. -S. [2 ]
Lu, S. -S. [5 ]
Lin, C. -W. [2 ]
Chang, P. -Z [4 ]
Shih, W. -P. [1 ]
机构
[1] Natl Taiwan Univ, Dept Mech Engn, Taipei 10764, Taiwan
[2] Natl Taiwan Univ, Inst Biomed Engn, Taipei, Taiwan
[3] Tamkang Univ, Dept Mech & Elect Mech Engn, Tamsui, Taiwan
[4] Natl Taiwan Univ, Inst Appl Mech, Taipei, Taiwan
[5] Natl Taiwan Univ, Dept Elect Engn, Taipei, Taiwan
关键词
GLUCOSE; BIOSENSOR;
D O I
10.1109/MEMSYS.2009.4805354
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
This paper presents the integration of the fabrication processes for an implantable multi-analyte biochip system. The implantable biochip system has a microfluidic channel in which an electrochemical biosensor and a dielectrophoresis (DEP) micropump are fabricated by surface micromachining. The enzyme-based biosensor consists of three electrodes and detects the glucose level instantaneously by utilizing glucose oxidase (GOD). The DEP force resulting from the four-phase voltage exchange of the interdigitated electrodes drives the blood flow in the microchannel. By utilizing the MEMS fabrication and the electric circuit design, a compact implantable biochip system is achieved.
引用
收藏
页码:204 / 207
页数:4
相关论文
共 50 条
  • [21] Automated fluidic system with a chaotic microfluidic reaction chamber for rapid, multi-analyte immunosensing
    Kai, Junhai
    Zoo, Zhiwei
    Han, Jungyoup
    Lee, Soo-Hyun
    Hong, Bin
    Ren, Yongjie
    Kang, Kyung A.
    Ahn, Chong H.
    TRANSDUCERS '07 & EUROSENSORS XXI, DIGEST OF TECHNICAL PAPERS, VOLS 1 AND 2, 2007,
  • [22] DEVELOPMENT OF A PORTABLE CEREBRAL MICRODIALYSIS PLATFORM FOR AUTOMATED INLINE MULTI-ANALYTE DETECTION SYSTEM
    Das, C.
    Agarwal, A.
    Nguyen, C.
    Wang, G.
    Ledden, B.
    Kumar, S.
    JOURNAL OF NEUROTRAUMA, 2014, 31 (12) : A18 - A18
  • [23] GeneSTAR(TM) multi-analyte detection system: Gastrointestinal bacterial pathogen panel.
    Meixell, G
    Glass, M
    Malmstrom, S
    Coombs, J
    Slade, L
    Radike, E
    Tautkus, G
    Wu, LX
    CLINICAL CHEMISTRY, 1996, 42 (11) : 38 - 38
  • [24] A new set up for multi-analyte sensing: At-line bio-process monitoring
    Akin, Mehriban
    Prediger, Andreas
    Yuksel, Merve
    Hoepfner, Tim
    Demirkol, Dilek Odaci
    Beutel, Sascha
    Timur, Suna
    Scheper, Thomas
    BIOSENSORS & BIOELECTRONICS, 2011, 26 (11): : 4532 - 4537
  • [25] Multi-analyte bioluminescence-based disposable ChemChips for home-based application: Update
    Andrade, Joseph
    Bartholomeusz, Daniel
    Davies, Rupert
    Yang, Xiaoyun
    Janatova, Jarmila
    ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS IV, 2006, 6080
  • [26] Multi-analyte study of circulating cytokines in smokers, with or without chronic obstructive pulmonary disease, and with or without lung cancer, using biochip array technology
    Duncan, Mark W.
    Gibson, David S.
    Bunn, Paul A., Jr.
    Spreafico, Anna
    Baron, Anna E.
    Wagner, Brandie
    Miller, York E.
    Toner, Vicki
    McConnell, Ivan
    Lamont, John V.
    FitzGerald, S. P.
    CYTOKINE, 2010, 52 (1-2) : 95 - 95
  • [27] An integrated clinical-genomics approach identifies a candidate multi-analyte blood test for serous ovarian carcinoma
    Meinhold-Heerlein, Ivo
    Bauerschlag, Dirk
    Zhou, Yingyao
    Sapinoso, Lisa M.
    Ching, Keith
    Frierson, Henry
    Braeutigam, Karen
    Sehouli, Jalid
    Stickeler, Elmar
    Koensgen, Dominique
    Hilpert, Felix
    von Kaisenberg, Constantin S.
    Pfisterer, Jacobus
    Bauknecht, Thomas
    Jonat, Walter
    Arnold, Norbert
    Hampton, Garret M.
    CLINICAL CANCER RESEARCH, 2007, 13 (02) : 458 - 466
  • [28] Monolithically Integrated Biosensors based on Frequency-Resolved Mach-Zehnder Interferometers for Multi-analyte determinations
    Petrou, Panagiota S.
    Kitsara, Maria
    Makarona, Eleni
    Raptis, Ioannis
    Kakabakos, Sotirios E.
    Stoffer, Remco
    Jobst, Gerhard
    Misiakos, Konstantinos
    2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2010, : 298 - 301
  • [29] Integration of a surface-directed microfluidic system with an organic electrochemical transistor array for multi-analyte biosensors
    Yang, Sang Y.
    DeFranco, John A.
    Sylvester, Yuri A.
    Gobert, Thomas J.
    Macaya, Daniel J.
    Owens, Roisin M.
    Malliaras, George G.
    LAB ON A CHIP, 2009, 9 (05) : 704 - 708
  • [30] Measures for optimizing pulsed EC-QC laser spectroscopy of liquids and application to multi-analyte blood analysis
    Brandstetter, M.
    Koch, C.
    Genner, A.
    Lendl, B.
    QUANTUM SENSING AND NANOPHOTONIC DEVICES XI, 2014, 8993