What Do You Get from DNA-Encoded Libraries?

被引：55
|
作者：
Satz, Alexander L. [1 ]
机构：
[1] F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Roche Pharma Res & Early Dev PRED, Grenzacherstr 124, CH-4070 Basel, Switzerland
来源：
ACS MEDICINAL CHEMISTRY LETTERS | 2018年 / 9卷 / 05期
关键词：
DNA-encoded libraries; screening; drug discovery; molecular diversity; combinatorial chemistry; microfluidics; SMALL-MOLECULE LIBRARY; TECHNOLOGY; SELECTION; RECEPTOR;
D O I：
10.1021/acsmedchemlett.8b00128
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Use of DNA-encoded libraries (DELs) in the pharmaceutical industry has rapidly increased. We discuss what to expect when you run a DEL screen and contemplate guidelines for library design. Additionally, we consider some visionary work and extrapolate to the future.
引用
收藏
页码：408 / 410
页数：5
相关论文
共 50 条
  • [41] Design, preparation, and selection of DNA-encoded dynamic libraries
    Li, Gang
    Zheng, Wenlu
    Chen, Zitian
    Zhou, Yu
    Liu, Yu
    Yang, Junrui
    Huang, Yanyi
    Li, Xiaoyu
    CHEMICAL SCIENCE, 2015, 6 (12) : 7097 - 7104
  • [42] Evolution of the Selection Methods of DNA-Encoded Chemical Libraries
    Song, Yinan
    Li, Xiaoyu
    ACCOUNTS OF CHEMICAL RESEARCH, 2021, 54 (17) : 3491 - 3503
  • [43] Diversified strategy for the synthesis of DNA-encoded oxindole libraries
    Wang, Xuan
    Liu, Jiaxiang
    Yan, Ziqin
    Liu, Xiaohong
    Liu, Sixiu
    Suo, Yanrui
    Lu, Weiwei
    Yue, Jinfeng
    Chen, Kaixian
    Jiang, Hualiang
    Zhao, Yujun
    Zheng, Mingyue
    Dai, Dongcheng
    Lu, Xiaojie
    CHEMICAL SCIENCE, 2021, 12 (08) : 2841 - 2847
  • [44] Macrocyclic DNA-encoded chemical libraries: a historical perspective
    Plais, Louise
    Scheuermann, Jorg
    RSC CHEMICAL BIOLOGY, 2022, 3 (01): : 7 - 17
  • [45] Protecting group strategies in the synthesis of DNA-encoded libraries
    Chilakapati, Sai Susheel
    Young, Damian
    Samuels, Errol
    Simmons, Nicholas
    Santini, Conrad
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [46] Recent Advances on the Selection Methods of DNA-Encoded Libraries
    Huang, Yiran
    Li, Xiaoyu
    CHEMBIOCHEM, 2021, 22 (14) : 2384 - 2397
  • [47] Fragment expansion with NUDELs - poised DNA-encoded libraries
    Salvini, Catherine L. A.
    Darlot, Benoit
    Davison, Jack
    Martin, Mathew P.
    Tudhope, Susan J.
    Turberville, Shannon
    Kawamura, Akane
    Noble, Martin E. M.
    Wedge, Stephen R.
    Crawford, James J.
    Waring, Michael J.
    CHEMICAL SCIENCE, 2023, 14 (31) : 8288 - 8294
  • [48] DNA-encoded libraries (DELs): a review of on-DNA chemistries and their output
    Shi, Ying
    Wu, Yan-ran
    Yu, Jian-qiang
    Zhang, Wan-nian
    Zhuang, Chun-lin
    RSC ADVANCES, 2021, 11 (04) : 2359 - 2376
  • [49] DNA-Compatible Copper/TEMPO Oxidation for DNA-Encoded Libraries
    Merrifield, Justice L.
    Pimentel, Edward B.
    Peters-Clarke, Trenton M.
    Nesbitt, Daniel J.
    Coon, Joshua J.
    Martell, Jeffrey D.
    BIOCONJUGATE CHEMISTRY, 2023, 34 (08) : 1380 - 1386
  • [50] DNA-Compatible Synthesis of α,β-Epoxyketones for DNA-Encoded Chemical Libraries
    Gao, Yuting
    Zhao, Guixian
    He, Pengyang
    Zhang, Gong
    Li, Yangfeng
    Li, Yizhou
    BIOCONJUGATE CHEMISTRY, 2022, 33 (01) : 105 - 110
12345