What Do You Get from DNA-Encoded Libraries?

被引：55
|
作者：
Satz, Alexander L. [1 ]
机构：
[1] F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Roche Pharma Res & Early Dev PRED, Grenzacherstr 124, CH-4070 Basel, Switzerland
来源：
ACS MEDICINAL CHEMISTRY LETTERS | 2018年 / 9卷 / 05期
关键词：
DNA-encoded libraries; screening; drug discovery; molecular diversity; combinatorial chemistry; microfluidics; SMALL-MOLECULE LIBRARY; TECHNOLOGY; SELECTION; RECEPTOR;
D O I：
10.1021/acsmedchemlett.8b00128
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Use of DNA-encoded libraries (DELs) in the pharmaceutical industry has rapidly increased. We discuss what to expect when you run a DEL screen and contemplate guidelines for library design. Additionally, we consider some visionary work and extrapolate to the future.
引用
收藏
页码：408 / 410
页数：5
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